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CD33

CD33 is a lectin (sialic acid binding Ig-like lectin 3) expressed mainly on cells of myeloid lineage and on some lymphoid cells. It is also known by acronyms such as p67, SIGLEC3, or SIGLEC-3. CD33 contains two immunoglobulin domains within its extracellular portion, one Ig-like C2 type domain and one Ig-like V type domain, respectively, and two immunoreceptor tyrosine-based inhibitor motifs (ITIM) in its cytoplasmic portion.

CD33 is speculated as an adhesion molecule of the myelomonocytic-derived cells and it has been proposed to participate in mediating sialic-acid dependent interactions, during which it shows high preference towards alpha-2,6-linked sialic acid. Upon ligand binding, CD33 exerts an action mode as an inhibitory receptor that blocks signal transduction and inhibits downstream cellular activities during immune responses. By far, CD33 is a classic target used in the treatment of acute myeloid leukemia by ADC-based immunotherapy by gemtuzumab ozogamicin (Mylotarg).

Entrez Gene ID: 945
UniProt ID: P20138