CD33
CD33 is a lectin (sialic acid binding Ig-like lectin 3) expressed mainly on cells of myeloid lineage and on some lymphoid cells. It is also known by acronyms such as p67, SIGLEC3, or SIGLEC-3. CD33 contains two immunoglobulin domains within its extracellular portion, one Ig-like C2 type domain and one Ig-like V type domain, respectively, and two immunoreceptor tyrosine-based inhibitor motifs (ITIM) in its cytoplasmic portion.
CD33 is speculated as an adhesion molecule of the myelomonocytic-derived cells and it has been proposed to participate in mediating sialic-acid dependent interactions, during which it shows high preference towards alpha-2,6-linked sialic acid. Upon ligand binding, CD33 exerts an action mode as an inhibitory receptor that blocks signal transduction and inhibits downstream cellular activities during immune responses. By far, CD33 is a classic target used in the treatment of acute myeloid leukemia by ADC-based immunotherapy by gemtuzumab ozogamicin (Mylotarg).
Entrez Gene ID: 945
UniProt ID: P20138
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| Catalog | Product name | Similar to | Antibody | Linker | Payload | Data sheet | Inquiry |
| ADC-W-426 | Anti-MSLN-disulfide linker-DM4 ADC | Human Anti-MSLN Antibody | Cleavable, disulfide linker | DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine) |
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Inquiry | |
| ADC-W-442 | Anti-MSLN ( MMOT-0530A)-MMAE ADC | Anti-MSLN Antibody, MMOT-0530A | protease-cleavable peptide linker | MMAE (Monomethyl auristatin E) |
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Inquiry | |
| ADC-W-454 | Anti-MSLN (clone h7D9.v3)-Mc-MMAF ADC | Humanized Anti-MSLN Antibody, clone # h7D9v3 | Mc (maleimidocaproyl) | MMAF (Monomethyl auristatin F) |
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Inquiry | |
| ADC-W-455 | Anti-MSLN (clone h7D9.v3)-Mc-VC-PABC-MMAE ADC | Humanized Anti-MSLN Antibody, clone # h7D9v3 | MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) | MMAE (Monomethyl auristatin E) |
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Inquiry | |
| ADC-W-456 | Anti-MSLN (clone h7D9.v3)-Mc-VC-PABC-MMAF ADC | Humanized Anti-MSLN Antibody, clone # h7D9v3 | MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) | MMAF (Monomethyl auristatin F) |
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Inquiry | |
ADC-W-474  |
Anti-MSLN-SPDB-DM4 ADC | anetumab ravtansine (BAY 94-9343) | Human Anti-MSLN lgG1 Antibody | SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate) | DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine) |
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Inquiry |
| ADC-W-1592 | Anti-MSLN (Amatuximab)-SMCC-DM1 ADC | Chimeric Anti-MSLN IgG1-kappa antibody, Amatuximab | SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate) | DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine) |
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Inquiry | |
| ADC-W-1593 | Anti-MSLN (Amatuximab)-SPDB-DM4 ADC | Chimeric Anti-MSLN IgG1-kappa antibody, Amatuximab | SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate) | DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine) |
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Inquiry | |
| ADC-W-1594 | Anti-MSLN (Amatuximab)-MC-MMAF ADC | Chimeric Anti-MSLN IgG1-kappa antibody, Amatuximab | MC (maleimidocaproyl) | MMAF |
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Inquiry | |
| ADC-W-1595 | Anti-MSLN (Amatuximab)-MC-Vc-PAB-MMAE ADC | Chimeric Anti-MSLN IgG1-kappa antibody, Amatuximab | MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) | MMAE |
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Inquiry | |
| ADC-W-1596 | Anti-MSLN (Amatuximab)-MC-Vc-PAB-SN38 ADC | Chimeric Anti-MSLN IgG1-kappa antibody, Amatuximab | MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) | SN-38 (7-ethyl-10-hydroxycamptothecin) |
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Inquiry | |
| ADC-W-1597 | Anti-MSLN (Amatuximab)-MC-Vc-PAB-DMEA-(PEG2)-duocarmycin SA ADC | Chimeric Anti-MSLN IgG1-kappa antibody, Amatuximab | MC-Vc-PAB-DMEA-(PEG2) | duocarmycin SA |
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Inquiry | |
| ADC-W-2560 | Anti-MSLN (Anetumab )-SMCC-DM1 ADC | Human Anti-MSLN IgG1-lambda antibody, Anetumab | SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate) | DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine) |
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Inquiry | |
| ADC-W-2561 | Anti-MSLN (Anetumab )-MC-MMAF ADC | Human Anti-MSLN IgG1-lambda antibody, Anetumab | MC (maleimidocaproyl) | MMAF |
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Inquiry | |
| ADC-W-2562 | Anti-MSLN (Anetumab )-MC-Vc-PAB-MMAE ADC | Human Anti-MSLN IgG1-lambda antibody, Anetumab | MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) | MMAE |
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Inquiry | |
| ADC-W-2563 | Anti-MSLN (Anetumab )-MC-Vc-PAB-SN38 ADC | Human Anti-MSLN IgG1-lambda antibody, Anetumab | MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) | SN-38 (7-ethyl-10-hydroxycamptothecin) |
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Inquiry | |
| ADC-W-2564 | Anti-MSLN (Anetumab )-MC-Vc-PAB-DMEA-(PEG2)-duocarmycin SA ADC | Human Anti-MSLN IgG1-lambda antibody, Anetumab | MC-Vc-PAB-DMEA-(PEG2) | duocarmycin SA |
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Inquiry |
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