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FGFR2

Fibroblast growth factor receptor 2 (FGFR2), also known as BEK, JWS, BBDS, CEK3, CFD1, ECT1, KGFR, TK14, TK25, BFR-1, CD332, and K-SAM, is a cell surface transmembrane receptor for acidic and basic fibroblast growth factors. FGFR2 is a highly-conserved Tyr protein kinase that contains three immunoglobulin-like C2-type domains, a single hydrophobic membrane-spanning domain, and one protein kinase domain in its sequence. The extracellular portion of FGFR2 interacts with the ligand, different form of fibroblast growth factors, and subsequently activates downstream cellular singling cascades that impacts cell mitogenesis and differentiation.

Mutations of FGFR2 is associated with a variety of diseases, including Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Mutation and abnormal expression of FGFR2 is also found in breast cancer, endometrial cancer, and melanoma, rending FGFR2 an appealing target for their prognosis and treatment via antibody-based immunotherapies.

Entrez Gene ID: 2263
UniProt ID: P21802