FGFR2
Fibroblast growth factor receptor 2 (FGFR2), also known as BEK, JWS, BBDS, CEK3, CFD1, ECT1, KGFR, TK14, TK25, BFR-1, CD332, and K-SAM, is a cell surface transmembrane receptor for acidic and basic fibroblast growth factors. FGFR2 is a highly-conserved Tyr protein kinase that contains three immunoglobulin-like C2-type domains, a single hydrophobic membrane-spanning domain, and one protein kinase domain in its sequence. The extracellular portion of FGFR2 interacts with the ligand, different form of fibroblast growth factors, and subsequently activates downstream cellular singling cascades that impacts cell mitogenesis and differentiation.
Mutations of FGFR2 is associated with a variety of diseases, including Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Mutation and abnormal expression of FGFR2 is also found in breast cancer, endometrial cancer, and melanoma, rending FGFR2 an appealing target for their prognosis and treatment via antibody-based immunotherapies.
Entrez Gene ID: 2263
UniProt ID: P21802
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| Catalog | Product name | Similar to | Antibody | Linker | Payload | Data sheet | Inquiry |
| ADC-W-051 | Anti-FGFR2 (clone 12425)-sulfo-SMCC-DM1 ADC | Human Anti-FGFR2 antibody, clone # 12425 | sulfo-SMCC (sulfosuccinimidyl 4-(N-maleimidomethyl) cyclohexane-l-carbox late) | DM1 (N2’-Deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine) |
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Inquiry | |
| ADC-W-052 | Anti-FGFR2 (clone 12433)-sulfo-SMCC-DM1 ADC | Human Anti-FGFR2 antibody, clone # 12433 | sulfo-SMCC (sulfosuccinimidyl 4-(N-maleimidomethyl) cyclohexane-l-carbox late) | DM1 (N2’-Deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine) |
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Inquiry | |
| ADC-W-053 | Anti-FGFR2 (clone 10164)-sulfo-SMCC-DM1 ADC | Human Anti-FGFR2 antibody, clone # 10164 | sulfo-SMCC (sulfosuccinimidyl 4-(N-maleimidomethyl) cyclohexane-l-carbox late) | DM1 (N2’-Deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine) |
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Inquiry | |
| ADC-W-054 | Anti-FGFR2 (clone 10220)-sulfo-SMCC-DM1 ADC | Human Anti-FGFR2 antibody, clone # 10220 | sulfo-SMCC (sulfosuccinimidyl 4-(N-maleimidomethyl) cyclohexane-l-carbox late) | DM1 (N2’-Deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine) |
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Inquiry | |
| ADC-W-055 | Anti-FGFR2 (clone 10918)-sulfo-SMCC-DM1 ADC | Human Anti-FGFR2 antibody, clone #10918 | sulfo-SMCC (sulfosuccinimidyl 4-(N-maleimidomethyl) cyclohexane-l-carbox late) | DM1 (N2’-Deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine) |
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Inquiry | |
| ADC-W-056 | Anti-FGFR2 (clone 10923)-sulfo-SMCC-DM1 ADC | Human Anti-FGFR2 antibody, clone # 10923 | sulfo-SMCC (sulfosuccinimidyl 4-(N-maleimidomethyl) cyclohexane-l-carbox late) | DM1 (N2’-Deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine) |
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Inquiry | |
| ADC-W-057 | Anti-FGFR2 (clone 11722)-sulfo-SMCC-DM1 ADC | Human Anti-FGFR2 antibody, clone # 11722 | sulfo-SMCC (sulfosuccinimidyl 4-(N-maleimidomethyl) cyclohexane-l-carbox late) | DM1 (N2’-Deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine) |
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Inquiry | |
| ADC-W-058 | Anti-FGFR2 (clone 12422)-sulfo-SMCC-DM1 ADC | Human Anti-FGFR2 antibody, clone # 12422 | sulfo-SMCC (sulfosuccinimidyl 4-(N-maleimidomethyl) cyclohexane-l-carbox late) | DM1 (N2’-Deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine) |
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Inquiry | |
| ADC-W-059 | Anti-FGFR2 (clone 12947)-sulfo-SMCC-DM1 ADC | Human Anti-FGFR2 antibody, clone # 12947 | sulfo-SMCC (sulfosuccinimidyl 4-(N-maleimidomethyl) cyclohexane-l-carbox late) | DM1 (N2’-Deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine) |
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Inquiry | |
| ADC-W-060 | Anti-FGFR2 (clone 12931)-sulfo-SMCC-DM1 ADC | Human Anti-FGFR2 antibody, clone # 12931 | sulfo-SMCC (sulfosuccinimidyl 4-(N-maleimidomethyl) cyclohexane-l-carbox late) | DM1 (N2’-Deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine) |
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Inquiry | |
| ADC-W-061 | Anti-FGFR2 (clone 12944)-sulfo-SMCC-DM1 ADC | Human Anti-FGFR2 antibody, clone # 12944 | sulfo-SMCC (sulfosuccinimidyl 4-(N-maleimidomethyl) cyclohexane-l-carbox late) | DM1 (N2’-Deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine) |
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Inquiry | |
| ADC-W-062 | Anti-FGFR2 (clone 12439)-sulfo-SMCC-DM1 ADC | Human Anti-FGFR2 antibody, clone # 12439 | sulfo-SMCC (sulfosuccinimidyl 4-(N-maleimidomethyl) cyclohexane-l-carbox late) | DM1 (N2’-Deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine) |
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Inquiry | |
| ADC-W-063 | Anti-FGFR2 (clone 10846)-sulfo-SMCC-DM1 ADC | Human Anti-FGFR2 antibody, clone # 10846 | sulfo-SMCC (sulfosuccinimidyl 4-(N-maleimidomethyl) cyclohexane-l-carbox late) | DM1 (N2’-Deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine) |
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Inquiry | |
| ADC-W-064 | Anti-FGFR2 (clone 11725)-sulfo-SMCC-DM1 ADC | Human Anti-FGFR2 antibody, clone # 11725 | sulfo-SMCC (sulfosuccinimidyl 4-(N-maleimidomethyl) cyclohexane-l-carbox late) | DM1 (N2’-Deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine) |
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Inquiry | |
| ADC-W-065 | Anti-FGFR2 (clone 11723)-sulfo-SMCC-DM1 ADC | Human Anti-FGFR2 antibody, clone # 11723 | sulfo-SMCC (sulfosuccinimidyl 4-(N-maleimidomethyl) cyclohexane-l-carbox late) | DM1 (N2’-Deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine) |
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Inquiry | |
| ADC-W-066 | Anti-FGFR2 (clone 12433)-SPDB-DM4 ADC | Human Anti-FGFR2 antibody, clone # 12433 | SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate) | DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine) |
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Inquiry | |
| ADC-W-557 | Anti-FGFR2-MMAE ADC | Anti-FGFR2 Antibody | MMAE (Monomethyl auristatin E) |
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Inquiry |
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