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IL23A

Interleukin-23 subunit alpha (IL23A), also named P19 or SGRF, is a protein that in humans is encoded by the IL23A gene. It is a heterodimeric cytokine made up of an IL-12p40 subunit which is shared with IL-12 and the IL-23p19 subunit. And IL23A is expressed by macrophages and dendritic cells, and is induced by microbial products, for example, LPS. The receptor of IL23A has been found which is comprised of IL-12R β1 and IL-23R.
IL-23 plays an important part in the pathogenesis of chronic inflammatory disorders, which is supported by the recent identification of IL-23 receptor susceptibility alleles associated with the inflammatory bowel diseases, psoriasis, and spondyloarthropathies. In addition, both IL23 and IL12 enable to induce the transcription activator STAT4, and activate the generation of interferon-gamma (IFNG). Different form IL12, which usually acts on naive CD4 (+) T cells, IL23 mainly acts on memory CD4 (+) T cells. What's more, it has proven that knockdown of AHR reduces the expression of IL23A in THP-1 cells and primary macrophage.
Gene ID: 51561
UniProt ID: Q9NPF7