ITGB3
Integrin subunit beta 3 (ITGB3), also known as GT, CD61, GP3A, BDPLT2, GPIIIa, or BDPLT16, is a protein subunit for integrins. Integrins are integral cell-surface proteins that contain several subunits, namely alpha chains and beta chains. They are known to participate in cell adhesion as well as cell-surface mediated signaling. Integrins are highly diverse in protein structures since a given subunit chain may combine with multiple partners. Integrin beta 3 is found in platelets along with the alpha IIb chain. Two isoforms of integrin beta 3, beta-3A and beta-3C have been identified and they exert different expression patterns: isoform beta-3A is specifically expressed in osteoblast cells while the expression of beta-3C is mainly in prostate and testis.
A defective in β3 integrin subunit expression has been demonstrated to correlate with endometriosis. It is also being used as a putative marker for this condition.
Entrez Gene ID: 3690
UniProt ID: P05106
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| Catalog | Product name | Similar to | Antibody | Linker | Payload | Data sheet | Inquiry |
| ADC-W-1340 | Anti-IL22 (Fezakinumab)-SMCC-DM1 ADC | Human Anti-IL22 IgG1-lambda antibody, Fezakinumab | SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate) | DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine) |
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Inquiry | |
| ADC-W-1341 | Anti-IL22 (Fezakinumab)-SPDB-DM4 ADC | Human Anti-IL22 IgG1-lambda antibody, Fezakinumab | SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate) | DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine) |
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Inquiry | |
| ADC-W-1342 | Anti-IL22 (Fezakinumab)-MC-MMAF ADC | Human Anti-IL22 IgG1-lambda antibody, Fezakinumab | MC (maleimidocaproyl) | MMAF |
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Inquiry | |
| ADC-W-1343 | Anti-IL22 (Fezakinumab)-MC-Vc-PAB-MMAE ADC | Human Anti-IL22 IgG1-lambda antibody, Fezakinumab | MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) | MMAE |
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Inquiry | |
| ADC-W-1344 | Anti-IL22 (Fezakinumab)-MC-Vc-PAB-SN38 ADC | Human Anti-IL22 IgG1-lambda antibody, Fezakinumab | MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) | SN-38 (7-ethyl-10-hydroxycamptothecin) |
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Inquiry | |
| ADC-W-1345 | Anti-IL22 (Fezakinumab)-MC-Vc-PAB-DMEA-(PEG2)-duocarmycin SA ADC | Human Anti-IL22 IgG1-lambda antibody, Fezakinumab | MC-Vc-PAB-DMEA-(PEG2) | duocarmycin SA |
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Inquiry |
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