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MSLN

Mesothelin (MSLN), also known as MPF, SMRP, CAK1 antigen or Pre-pro-megakaryocyte-potentiating factor, is a 40 kDa glycosylphosphatidylinositol-anchored glycoprotein. The MSLN gene encodes a preproprotein that is proteolytically processed to generate two protein products, megakaryocyte potentiating factor and mesothelin. As a glycosylphosphatidylinositol-anchored cell-surface protein, mesothelin may function as a cell adhesion protein, while megakaryocyte potentiating factor functions as a cytokine stimulating colony formation of bone marrow megakaryocytes.

It is reported that mature human mesothelin shares 60% amino acid identity with mouse and rat mesothelin. This mesothelin protein is found to be expressed on mesothelial cells in the pleura, pericardium and peritoneum, and it is overexpressed in multiple cancers including epithelial mesotheliomas, ovarian cancers as well as specific squamous cell carcinomas. This protein can serve as a potential target for various cancer immunotherapy strategies, including monoclonal antibody, immunotoxin and antibody-drug conjugate (ADC).

Gene ID: 10232
UniProt ID: Q13421