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TNFRSF10B

TNF receptor superfamily member 10b (TNFRSF10B), also known as Death receptor 5 (DR5), CD262, KILLER, TRICK2, TRICKB, ZTNFR9 or TRAIL receptor 2 (TRAILR2), is a type 1 membrane protein that belongs to the TNF-receptor superfamily. The TNFRSF10B gene encodes a 440-amino acid residue precursor protein containing extracellular cysteine-rich domains, a transmembrane domain and a cytoplasmic death domain. The TNFRSF10B protein is a receptor for tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L) and it can be activated by those ligands. After activation, the adapter molecule FADD recruits caspase-8 to the activated receptor to form the death-inducing signaling complex (DISC), resulting in caspase-8 proteolytic activation and the subsequent cascade of caspases mediating apoptosis.

This protein is widely expressed in numerous tissues, such as heart, liver, pancreas, spleen, thymus, prostate, ovary, uterus, placenta, stomach, intestinal tract as well as peripheral blood lymphocytes, and it is highly expressed in tumor cell lines that include HeLaS3, K-562, HL-60, SW480, A-549 and G-361. Notably, monoclonal antibodies targeting TNFRSF10B have been developed and are currently under clinical trials for patients suffer from a variety of cancer types, for example, Tigatuzumab (also called CS-1008).

Gene ID: 8795
UniProt ID: O14763