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Ad Fiber Knob & ITGAV Bispecific Antibodies
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CAT# Product Name Species Reactivity BsAb Type Target 1 Target 2 INQUIRY
T-BSDB-005 Recombinant Anti-Ad Fiber Knob x Anti-ITGAV Bispecific Antibody (Tandem Diabody) Human Ad Fiber Knob ITGAV Inquiry
SCIGG-005 Recombinant Anti-Ad Fiber Knob x Anti-ITGAV Bispecific Antibody (scIgG) Human Single chain IgGs Ad Fiber Knob ITGAV Inquiry
FVTIG-005 Recombinant Anti-Ad Fiber Knob x Anti-ITGAV Bispecific Antibody (scFv4-Ig) Human Appended IgGs Ad Fiber Knob ITGAV Inquiry
BSSG-005 Recombinant Anti-Ad Fiber Knob x Anti-ITGAV Bispecific Antibody (scFv-IgG) Human Appended IgGs Ad Fiber Knob ITGAV Inquiry
IGLFV-005 Recombinant Anti-Ad Fiber Knob x Anti-ITGAV Bispecific Antibody (IgG(L)-scFv) Human Appended IgGs Ad Fiber Knob ITGAV Inquiry
BSGV-005 Recombinant Anti-Ad Fiber Knob x Anti-ITGAV Bispecific Antibody (IgG-Fv) Human IgG-Fv Ad Fiber Knob ITGAV Inquiry
BSDG-005 Recombinant Anti-Ad Fiber Knob x Anti-ITGAV Bispecific Antibody (Fv-IgG) Human Appended IgGs Ad Fiber Knob ITGAV Inquiry
BABFV-005 Recombinant Anti-Ad Fiber Knob x Anti-ITGAV Bispecific Antibody (F(ab')2-scFv2) Human Fab-Fc Fusion Proteins Ad Fiber Knob ITGAV Inquiry
FABVC-005 Recombinant Anti-Ad Fiber Knob x Anti-ITGAV Bispecific Antibody (Fab-scFv-Fc) Human Fab-Fc Fusion Proteins Ad Fiber Knob ITGAV Inquiry
SCDBC-005 Recombinant Anti-Ad Fiber Knob x Anti-ITGAV Bispecific Antibody (scDiabody-CH3) Human Constant Domain-extended Bispecific Fragments Ad Fiber Knob ITGAV Inquiry
BSDBC-005 Recombinant Anti-Ad Fiber Knob x Anti-ITGAV Bispecific Antibody (Diabody-CH3) Human Constant Domain-extended Bispecific Fragments Ad Fiber Knob ITGAV Inquiry
SCDBF-005 Recombinant Anti-Ad Fiber Knob x Anti-ITGAV Bispecific Antibody (scDiabody-Fc) Human Constant Domain-extended Bispecific Fragments Ad Fiber Knob ITGAV Inquiry
BSFVF-005 Recombinant Anti-Ad Fiber Knob x Anti-ITGAV Bispecific Antibody (Tandem scFv-Fc) Human Constant Domain-extended Bispecific Fragments Ad Fiber Knob ITGAV Inquiry
BSDBF-005 Recombinant Anti-Ad Fiber Knob x Anti-ITGAV Bispecific Antibody (Diabody-Fc) Human Constant Domain-extended Bispecific Fragments Ad Fiber Knob ITGAV Inquiry
BSTF-005 Recombinant Anti-Ad Fiber Knob x Anti-ITGAV Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv Ad Fiber Knob ITGAV Inquiry
BSCFV-005 Recombinant Anti-Ad Fiber Knob x Anti-ITGAV Bispecific Antibody (scFv-Fc) Human scFv-Fc Ad Fiber Knob ITGAV Inquiry
MNAB-005 Recombinant Anti-Ad Fiber Knob x Anti-ITGAV Bispecific Antibody (Miniantibody) Human Miniantibody Ad Fiber Knob ITGAV Inquiry
BSFC-005 Recombinant Anti-Ad Fiber Knob x Anti-ITGAV Bispecific Antibody (scFv-CH3) Human scFv-CH3 Ad Fiber Knob ITGAV Inquiry
BSCC-005 Recombinant Anti-Ad Fiber Knob x Anti-ITGAV Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL Ad Fiber Knob ITGAV Inquiry
BIBD-005 Recombinant Anti-Ad Fiber Knob x Anti-ITGAV Bispecific Antibody (Bibody) Human Bibody Ad Fiber Knob ITGAV Inquiry
FABFV-005 Recombinant Anti-Ad Fiber Knob x Anti-ITGAV Bispecific Antibody (Fab-Fv) Human Fab-Fv Ad Fiber Knob ITGAV Inquiry
MiniB-005 Recombinant Anti-Ad Fiber Knob x Anti-ITGAV Bispecific Antibody (Minibody) Human Minibody Ad Fiber Knob ITGAV Inquiry
SCDB-005 Recombinant Anti-Ad Fiber Knob x Anti-ITGAV Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody Ad Fiber Knob ITGAV Inquiry
FABIG-005 Recombinant Anti-Ad Fiber Knob x Anti-ITGAV Bispecific Antibody (Fab-IgG) Human Fab-IgG Ad Fiber Knob ITGAV Inquiry
TRIB-005 Recombinant Anti-Ad Fiber Knob x Anti-ITGAV Bispecific Antibody (Triple Body) Human Triple Body Ad Fiber Knob ITGAV Inquiry
BSIG-005 Anti-Ad Fiber Knob x Anti-ITGAV Bispecific Antibody (IgG-IgG) Human IgG-IgG Ad Fiber Knob ITGAV Inquiry
CROSSAB-005 Recombinant Anti-Ad Fiber Knob x Anti-ITGAV Bispecific Antibody (CrossMab) Human CrossMab Ad Fiber Knob ITGAV Inquiry
IGFV-005 Recombinant Anti-Ad Fiber Knob x Anti-ITGAV Bispecific Antibody (IgG-scFv) Human IgG-scFv Ad Fiber Knob ITGAV Inquiry
BSDB-005 Recombinant Anti-Ad Fiber Knob x Anti-ITGAV Bispecific Antibody (Diabody) Human Diabody Ad Fiber Knob ITGAV Inquiry
BSFAB-005 Recombinant Anti-Ad Fiber Knob x Anti-ITGAV Bispecific Antibody (Tandem Fab) Human Tandem Fab Ad Fiber Knob ITGAV Inquiry
BSFV-005 Recombinant Anti-Ad Fiber Knob x Anti-ITGAV Bispecific Antibody (Tandem scFv) Human Tandem scFv Ad Fiber Knob ITGAV Inquiry
BSDG-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (Fv-IgG) Human Appended IgGs Ad Fiber Knob EPCAM Inquiry
BSDG-003 Recombinant Anti-Ad Fiber Knob x Anti-CEA Bispecific Antibody (Fv-IgG) Human Appended IgGs Ad Fiber Knob CEA Inquiry
BSDG-002 Recombinant Anti-Ad Fiber Knob x Anti-CD40 Bispecific Antibody (Fv-IgG) Human Appended IgGs Ad Fiber Knob CD40 Inquiry
BABFV-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (F(ab')2-scFv2) Human Fab-Fc Fusion Proteins Ad Fiber Knob EPCAM Inquiry
BABFV-003 Recombinant Anti-Ad Fiber Knob x Anti-CEA Bispecific Antibody (F(ab')2-scFv2) Human Fab-Fc Fusion Proteins Ad Fiber Knob CEA Inquiry
BABFV-002 Recombinant Anti-Ad Fiber Knob x Anti-CD40 Bispecific Antibody (F(ab')2-scFv2) Human Fab-Fc Fusion Proteins Ad Fiber Knob CD40 Inquiry
FABVC-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (Fab-scFv-Fc) Human Fab-Fc Fusion Proteins Ad Fiber Knob EPCAM Inquiry
FABVC-003 Recombinant Anti-Ad Fiber Knob x Anti-CEA Bispecific Antibody (Fab-scFv-Fc) Human Fab-Fc Fusion Proteins Ad Fiber Knob CEA Inquiry
FABVC-002 Recombinant Anti-Ad Fiber Knob x Anti-CD40 Bispecific Antibody (Fab-scFv-Fc) Human Fab-Fc Fusion Proteins Ad Fiber Knob CD40 Inquiry
SCDBC-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (scDiabody-CH3) Human Constant Domain-extended Bispecific Fragments Ad Fiber Knob EPCAM Inquiry
SCDBC-003 Recombinant Anti-Ad Fiber Knob x Anti-CEA Bispecific Antibody (scDiabody-CH3) Human Constant Domain-extended Bispecific Fragments Ad Fiber Knob CEA Inquiry
SCDBC-002 Recombinant Anti-Ad Fiber Knob x Anti-CD40 Bispecific Antibody (scDiabody-CH3) Human Constant Domain-extended Bispecific Fragments Ad Fiber Knob CD40 Inquiry
BSDBC-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (Diabody-CH3) Human Constant Domain-extended Bispecific Fragments Ad Fiber Knob EPCAM Inquiry
BSDBC-003 Recombinant Anti-Ad Fiber Knob x Anti-CEA Bispecific Antibody (Diabody-CH3) Human Constant Domain-extended Bispecific Fragments Ad Fiber Knob CEA Inquiry
BSDBC-002 Recombinant Anti-Ad Fiber Knob x Anti-CD40 Bispecific Antibody (Diabody-CH3) Human Constant Domain-extended Bispecific Fragments Ad Fiber Knob CD40 Inquiry
SCDBF-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (scDiabody-Fc) Human Constant Domain-extended Bispecific Fragments Ad Fiber Knob EPCAM Inquiry
SCDBF-003 Recombinant Anti-Ad Fiber Knob x Anti-CEA Bispecific Antibody (scDiabody-Fc) Human Constant Domain-extended Bispecific Fragments Ad Fiber Knob CEA Inquiry
SCDBF-002 Recombinant Anti-Ad Fiber Knob x Anti-CD40 Bispecific Antibody (scDiabody-Fc) Human Constant Domain-extended Bispecific Fragments Ad Fiber Knob CD40 Inquiry
BSFVF-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (Tandem scFv-Fc) Human Constant Domain-extended Bispecific Fragments Ad Fiber Knob EPCAM Inquiry
BSFVF-003 Recombinant Anti-Ad Fiber Knob x Anti-CEA Bispecific Antibody (Tandem scFv-Fc) Human Constant Domain-extended Bispecific Fragments Ad Fiber Knob CEA Inquiry
BSFVF-002 Recombinant Anti-Ad Fiber Knob x Anti-CD40 Bispecific Antibody (Tandem scFv-Fc) Human Constant Domain-extended Bispecific Fragments Ad Fiber Knob CD40 Inquiry
BSDBF-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (Diabody-Fc) Human Constant Domain-extended Bispecific Fragments Ad Fiber Knob EPCAM Inquiry
BSDBF-003 Recombinant Anti-Ad Fiber Knob x Anti-CEA Bispecific Antibody (Diabody-Fc) Human Constant Domain-extended Bispecific Fragments Ad Fiber Knob CEA Inquiry
BSDBF-002 Recombinant Anti-Ad Fiber Knob x Anti-CD40 Bispecific Antibody (Diabody-Fc) Human Constant Domain-extended Bispecific Fragments Ad Fiber Knob CD40 Inquiry
BSTF-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv Ad Fiber Knob EPCAM Inquiry
BSTF-003 Recombinant Anti-Ad Fiber Knob x Anti-CEA Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv Ad Fiber Knob CEA Inquiry
BSTF-002 Recombinant Anti-Ad Fiber Knob x Anti-CD40 Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv Ad Fiber Knob CD40 Inquiry
BSCFV-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (scFv-Fc) Human scFv-Fc Ad Fiber Knob EPCAM Inquiry
BSCFV-003 Recombinant Anti-Ad Fiber Knob x Anti-CEA Bispecific Antibody (scFv-Fc) Human scFv-Fc Ad Fiber Knob CEA Inquiry
BSCFV-002 Recombinant Anti-Ad Fiber Knob x Anti-CD40 Bispecific Antibody (scFv-Fc) Human scFv-Fc Ad Fiber Knob CD40 Inquiry
MNAB-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (Miniantibody) Human Miniantibody Ad Fiber Knob EPCAM Inquiry
MNAB-003 Recombinant Anti-Ad Fiber Knob x Anti-CEA Bispecific Antibody (Miniantibody) Human Miniantibody Ad Fiber Knob CEA Inquiry
MNAB-002 Recombinant Anti-Ad Fiber Knob x Anti-CD40 Bispecific Antibody (Miniantibody) Human Miniantibody Ad Fiber Knob CD40 Inquiry
BSFC-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (scFv-CH3) Human scFv-CH3 Ad Fiber Knob EPCAM Inquiry
BSFC-003 Recombinant Anti-Ad Fiber Knob x Anti-CEA Bispecific Antibody (scFv-CH3) Human scFv-CH3 Ad Fiber Knob CEA Inquiry
BSFC-002 Recombinant Human Anti-Ad Fiber Knob x Anti-CD40 Bispecific Antibody (scFv-CH3) Human scFv-based Bispecific Fragments Ad Fiber Knob CD40 Inquiry
BSCC-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL Ad Fiber Knob EPCAM Inquiry
BSCC-003 Recombinant Anti-Ad Fiber Knob x Anti-CEA Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL Ad Fiber Knob CEA Inquiry
BSCC-002 Recombinant Anti-Ad Fiber Knob x Anti-CD40 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL Ad Fiber Knob CD40 Inquiry
BIBD-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (Bibody) Human Bibody Ad Fiber Knob EPCAM Inquiry
BIBD-003 Recombinant Anti-Ad Fiber Knob x Anti-CEA Bispecific Antibody (Bibody) Human Bibody Ad Fiber Knob CEA Inquiry
BIBD-002 Recombinant Anti-Ad Fiber Knob x Anti-CD40 Bispecific Antibody (Bibody) Human Bibody Ad Fiber Knob CD40 Inquiry
FABFV-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (Fab-Fv) Human Fab-Fv Ad Fiber Knob EPCAM Inquiry
FABFV-003 Recombinant Anti-Ad Fiber Knob x Anti-CEA Bispecific Antibody (Fab-Fv) Human Fab-Fv Ad Fiber Knob CEA Inquiry
FABFV-002 Recombinant Anti-Ad Fiber Knob x Anti-CD40 Bispecific Antibody (Fab-Fv) Human Fab-Fv Ad Fiber Knob CD40 Inquiry
MiniB-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (Minibody) Human Minibody Ad Fiber Knob EPCAM Inquiry
MiniB-003 Recombinant Anti-Ad Fiber Knob x Anti-CEA Bispecific Antibody (Minibody) Human Minibody Ad Fiber Knob CEA Inquiry
MiniB-002 Recombinant Anti-Ad Fiber Knob x Anti-CD40 Bispecific Antibody (Minibody) Human Minibody Ad Fiber Knob CD40 Inquiry
SCDB-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody Ad Fiber Knob EPCAM Inquiry
SCDB-003 Recombinant Anti-Ad Fiber Knob x Anti-CEA Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody Ad Fiber Knob CEA Inquiry
SCDB-002 Recombinant Anti-Ad Fiber Knob x Anti-CD40 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody Ad Fiber Knob CD40 Inquiry
FABIG-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (Fab-IgG) Human Fab-IgG Ad Fiber Knob EPCAM Inquiry
FABIG-003 Recombinant Anti-Ad Fiber Knob x Anti-CEA Bispecific Antibody (Fab-IgG) Human Fab-IgG Ad Fiber Knob CEA Inquiry
FABIG-002 Recombinant Anti-Ad Fiber Knob x Anti-CD40 Bispecific Antibody (Fab-IgG) Human Fab-IgG Ad Fiber Knob CD40 Inquiry
TRIB-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (Triple Body) Human Triple Body Ad Fiber Knob EPCAM Inquiry
TRIB-003 Recombinant Anti-Ad Fiber Knob x Anti-CEA Bispecific Antibody (Triple Body) Human Triple Body Ad Fiber Knob CEA Inquiry
TRIB-002 Recombinant Anti-Ad Fiber Knob x Anti-CD40 Bispecific Antibody (Triple Body) Human Triple Body Ad Fiber Knob CD40 Inquiry
BSIG-004 Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (IgG-IgG) Human IgG-IgG Ad Fiber Knob EPCAM Inquiry
BSIG-003 Anti-Ad Fiber Knob x Anti-CEA Bispecific Antibody (IgG-IgG) Human IgG-IgG Ad Fiber Knob CEA Inquiry
BSIG-002 Anti-Ad Fiber Knob x Anti-CD40 Bispecific Antibody (IgG-IgG) Human IgG-IgG Ad Fiber Knob CD40 Inquiry
CROSSAB-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (CrossMab) Human CrossMab Ad Fiber Knob EPCAM Inquiry
CROSSAB-003 Recombinant Anti-Ad Fiber Knob x Anti-CEA Bispecific Antibody (CrossMab) Human CrossMab Ad Fiber Knob CEA Inquiry
CROSSAB-002 Recombinant Anti-Ad Fiber Knob x Anti-CD40 Bispecific Antibody (CrossMab) Human CrossMab Ad Fiber Knob CD40 Inquiry
IGFV-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (IgG-scFv) Human IgG-scFv Ad Fiber Knob EPCAM Inquiry
IGFV-003 Recombinant Anti-Ad Fiber Knob x Anti-CEA Bispecific Antibody (IgG-scFv) Human IgG-scFv Ad Fiber Knob CEA Inquiry
IGFV-002 Recombinant Anti-Ad Fiber Knob x Anti-CD40 Bispecific Antibody (IgG-scFv) Human IgG-scFv Ad Fiber Knob CD40 Inquiry
BSDB-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (Diabody) Human Diabody Ad Fiber Knob EPCAM Inquiry
BSDB-003 Recombinant Anti-Ad Fiber Knob x Anti-CEA Bispecific Antibody (Diabody) Human Diabody Ad Fiber Knob CEA Inquiry
BSDB-002 Recombinant Anti-Ad Fiber Knob x Anti-CD40 Bispecific Antibody (Diabody) Human Diabody Ad Fiber Knob CD40 Inquiry
BSFAB-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (Tandem Fab) Human Tandem Fab Ad Fiber Knob EPCAM Inquiry
BSFAB-003 Recombinant Anti-Ad Fiber Knob x Anti-CEA Bispecific Antibody (Tandem Fab) Human Tandem Fab Ad Fiber Knob CEA Inquiry
BSFAB-002 Recombinant Anti-Ad Fiber Knob x Anti-CD40 Bispecific Antibody (Tandem Fab) Human Tandem Fab Ad Fiber Knob CD40 Inquiry
BSFV-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (Tandem scFv) Human Tandem scFv Ad Fiber Knob EPCAM Inquiry
BSFV-003 Recombinant Anti-Ad Fiber Knob x Anti-CEA Bispecific Antibody (Tandem scFv) Human Tandem scFv Ad Fiber Knob CEA Inquiry
BSFV-002 Recombinant Human Anti-Ad Fiber Knob x Anti-CD40 Bispecific Antibody (Tandem scFv) Human Tandem scFv Ad Fiber Knob CD40 Inquiry

Background

The Ad fiber knob refers to the fiber protein found on the surface of adenoviruses, which plays a crucial role in viral attachment and entry into host cells. ITGAV (integrin alpha V) is a cell surface protein that regulates angiogenesis, cell proliferation, migration, and invasion in a variety of tumors. The anti-Ad fiber knob×anti-ITGAV bispecific antibody (BsAb) can be constructed as a novel therapeutic agent that functions by simultaneously binding to the Ad fiber knob and ITGAV. This dual bind allows for the selective delivery of gene therapy vectors to ITGAV-expressing tumor cells, enhancing the specificity and efficiency of adenoviral gene therapy. Additionally, the BsAb can activate immune cells against ITGAV-expressing tumor cells. This BsAb can be potentially used in targeted gene therapy for cancer, particularly cancers that overexpress ITGAV, such as melanoma, prostate cancer, and breast cancer.

Fig.1 Ad fiber knob and ITGAV structures. (Stasiak, et al., 2020; https://commons.wikimedia.org/wiki/File:PDB_1jv2_EBI.jpg) Fig.1 Structures of Ad fiber knob and ITGAV.1,2

References

  1. Stasiak, Aleksandra Cecylia, and Thilo Stehle. "Human adenovirus binding to host cell receptors: A structural view." Medical microbiology and immunology 209.3 (2020): 325-333.
  2. From Wikipedia: Public Domain, https://commons.wikimedia.org/wiki/File:PDB_1jv2_EBI.jpg
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