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Ad Fiber Knob & CD40 Bispecific Antibodies
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CAT# Product Name Species Reactivity BsAb Type Target 1 Target 2 INQUIRY
T-BSDB-002 Recombinant Anti-Ad Fiber Knob x Anti-CD40 Bispecific Antibody (Tandem Diabody) Human Ad Fiber Knob CD40 Inquiry
SCIGG-002 Recombinant Anti-Ad Fiber Knob x Anti-CD40 Bispecific Antibody (scIgG) Human Single chain IgGs Ad Fiber Knob CD40 Inquiry
FVTIG-002 Recombinant Anti-Ad Fiber Knob x Anti-CD40 Bispecific Antibody (scFv4-Ig) Human Appended IgGs Ad Fiber Knob CD40 Inquiry
BSSG-002 Recombinant Anti-Ad Fiber Knob x Anti-CD40 Bispecific Antibody (scFv-IgG) Human Appended IgGs Ad Fiber Knob CD40 Inquiry
IGLFV-002 Recombinant Anti-Ad Fiber Knob x Anti-CD40 Bispecific Antibody (IgG(L)-scFv) Human Appended IgGs Ad Fiber Knob CD40 Inquiry
BSGV-002 Recombinant Anti-Ad Fiber Knob x Anti-CD40 Bispecific Antibody (IgG-Fv) Human IgG-Fv Ad Fiber Knob CD40 Inquiry
BSDG-002 Recombinant Anti-Ad Fiber Knob x Anti-CD40 Bispecific Antibody (Fv-IgG) Human Appended IgGs Ad Fiber Knob CD40 Inquiry
BABFV-002 Recombinant Anti-Ad Fiber Knob x Anti-CD40 Bispecific Antibody (F(ab')2-scFv2) Human Fab-Fc Fusion Proteins Ad Fiber Knob CD40 Inquiry
FABVC-002 Recombinant Anti-Ad Fiber Knob x Anti-CD40 Bispecific Antibody (Fab-scFv-Fc) Human Fab-Fc Fusion Proteins Ad Fiber Knob CD40 Inquiry
SCDBC-002 Recombinant Anti-Ad Fiber Knob x Anti-CD40 Bispecific Antibody (scDiabody-CH3) Human Constant Domain-extended Bispecific Fragments Ad Fiber Knob CD40 Inquiry
BSDBC-002 Recombinant Anti-Ad Fiber Knob x Anti-CD40 Bispecific Antibody (Diabody-CH3) Human Constant Domain-extended Bispecific Fragments Ad Fiber Knob CD40 Inquiry
SCDBF-002 Recombinant Anti-Ad Fiber Knob x Anti-CD40 Bispecific Antibody (scDiabody-Fc) Human Constant Domain-extended Bispecific Fragments Ad Fiber Knob CD40 Inquiry
BSFVF-002 Recombinant Anti-Ad Fiber Knob x Anti-CD40 Bispecific Antibody (Tandem scFv-Fc) Human Constant Domain-extended Bispecific Fragments Ad Fiber Knob CD40 Inquiry
BSDBF-002 Recombinant Anti-Ad Fiber Knob x Anti-CD40 Bispecific Antibody (Diabody-Fc) Human Constant Domain-extended Bispecific Fragments Ad Fiber Knob CD40 Inquiry
BSTF-002 Recombinant Anti-Ad Fiber Knob x Anti-CD40 Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv Ad Fiber Knob CD40 Inquiry
BSCFV-002 Recombinant Anti-Ad Fiber Knob x Anti-CD40 Bispecific Antibody (scFv-Fc) Human scFv-Fc Ad Fiber Knob CD40 Inquiry
MNAB-002 Recombinant Anti-Ad Fiber Knob x Anti-CD40 Bispecific Antibody (Miniantibody) Human Miniantibody Ad Fiber Knob CD40 Inquiry
BSFC-002 Recombinant Human Anti-Ad Fiber Knob x Anti-CD40 Bispecific Antibody (scFv-CH3) Human scFv-based Bispecific Fragments Ad Fiber Knob CD40 Inquiry
BSCC-002 Recombinant Anti-Ad Fiber Knob x Anti-CD40 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL Ad Fiber Knob CD40 Inquiry
BIBD-002 Recombinant Anti-Ad Fiber Knob x Anti-CD40 Bispecific Antibody (Bibody) Human Bibody Ad Fiber Knob CD40 Inquiry
FABFV-002 Recombinant Anti-Ad Fiber Knob x Anti-CD40 Bispecific Antibody (Fab-Fv) Human Fab-Fv Ad Fiber Knob CD40 Inquiry
MiniB-002 Recombinant Anti-Ad Fiber Knob x Anti-CD40 Bispecific Antibody (Minibody) Human Minibody Ad Fiber Knob CD40 Inquiry
SCDB-002 Recombinant Anti-Ad Fiber Knob x Anti-CD40 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody Ad Fiber Knob CD40 Inquiry
FABIG-002 Recombinant Anti-Ad Fiber Knob x Anti-CD40 Bispecific Antibody (Fab-IgG) Human Fab-IgG Ad Fiber Knob CD40 Inquiry
TRIB-002 Recombinant Anti-Ad Fiber Knob x Anti-CD40 Bispecific Antibody (Triple Body) Human Triple Body Ad Fiber Knob CD40 Inquiry
BSIG-002 Anti-Ad Fiber Knob x Anti-CD40 Bispecific Antibody (IgG-IgG) Human IgG-IgG Ad Fiber Knob CD40 Inquiry
CROSSAB-002 Recombinant Anti-Ad Fiber Knob x Anti-CD40 Bispecific Antibody (CrossMab) Human CrossMab Ad Fiber Knob CD40 Inquiry
IGFV-002 Recombinant Anti-Ad Fiber Knob x Anti-CD40 Bispecific Antibody (IgG-scFv) Human IgG-scFv Ad Fiber Knob CD40 Inquiry
BSDB-002 Recombinant Anti-Ad Fiber Knob x Anti-CD40 Bispecific Antibody (Diabody) Human Diabody Ad Fiber Knob CD40 Inquiry
BSFAB-002 Recombinant Anti-Ad Fiber Knob x Anti-CD40 Bispecific Antibody (Tandem Fab) Human Tandem Fab Ad Fiber Knob CD40 Inquiry
BSFV-002 Recombinant Human Anti-Ad Fiber Knob x Anti-CD40 Bispecific Antibody (Tandem scFv) Human Tandem scFv Ad Fiber Knob CD40 Inquiry
BSTF-003 Recombinant Anti-Ad Fiber Knob x Anti-CEA Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv Ad Fiber Knob CEA Inquiry
BSCFV-H232 Recombinant Human Anti-CD28 x Human Anti-CD40 Bispecific Antibody (scFv-Fc) Human scFv-based Bispecific Fragments CD28 CD40 Inquiry
BSCFV-056 Recombinant Anti-CD28 x Anti-CD40 Bispecific Antibody (scFv-Fc) Human scFv-based Bispecific Fragments CD28 CD40 Inquiry
BSCFV-005 Recombinant Anti-Ad Fiber Knob x Anti-ITGAV Bispecific Antibody (scFv-Fc) Human scFv-Fc Ad Fiber Knob ITGAV Inquiry
BSCFV-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (scFv-Fc) Human scFv-Fc Ad Fiber Knob EPCAM Inquiry
BSCFV-003 Recombinant Anti-Ad Fiber Knob x Anti-CEA Bispecific Antibody (scFv-Fc) Human scFv-Fc Ad Fiber Knob CEA Inquiry
MNAB-H232 Recombinant Human Anti-CD28 x Human Anti-CD40 Bispecific Antibody (Miniantibody) Human scFv-based Bispecific Fragments CD28 CD40 Inquiry
MNAB-056 Recombinant Anti-CD28 x Anti-CD40 Bispecific Antibody (Miniantibody) Human scFv-based Bispecific Fragments CD28 CD40 Inquiry
MNAB-005 Recombinant Anti-Ad Fiber Knob x Anti-ITGAV Bispecific Antibody (Miniantibody) Human Miniantibody Ad Fiber Knob ITGAV Inquiry
MNAB-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (Miniantibody) Human Miniantibody Ad Fiber Knob EPCAM Inquiry
MNAB-003 Recombinant Anti-Ad Fiber Knob x Anti-CEA Bispecific Antibody (Miniantibody) Human Miniantibody Ad Fiber Knob CEA Inquiry
BSFC-H232 Recombinant Human Anti-CD28 x Human Anti-CD40 Bispecific Antibody (scFv-CH3) Human scFv-based Bispecific Fragments CD28 CD40 Inquiry
BSFC-056 Recombinant Anti-CD28 x Anti-CD40 Bispecific Antibody (scFv-CH3) Human scFv-based Bispecific Fragments CD28 CD40 Inquiry
BSFC-005 Recombinant Anti-Ad Fiber Knob x Anti-ITGAV Bispecific Antibody (scFv-CH3) Human scFv-CH3 Ad Fiber Knob ITGAV Inquiry
BSFC-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (scFv-CH3) Human scFv-CH3 Ad Fiber Knob EPCAM Inquiry
BSFC-003 Recombinant Anti-Ad Fiber Knob x Anti-CEA Bispecific Antibody (scFv-CH3) Human scFv-CH3 Ad Fiber Knob CEA Inquiry
BSCC-H232 Recombinant Human Anti-CD28 x Human Anti-CD40 Bispecific Antibody (scFv-CH1/CL) Human scFv-based Bispecific Fragments CD28 CD40 Inquiry
BSCC-056 Recombinant Anti-CD28 x Anti-CD40 Bispecific Antibody (scFv-CH1/CL) Human scFv-based Bispecific Fragments CD28 CD40 Inquiry
BSCC-005 Recombinant Anti-Ad Fiber Knob x Anti-ITGAV Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL Ad Fiber Knob ITGAV Inquiry
BSCC-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL Ad Fiber Knob EPCAM Inquiry
BSCC-003 Recombinant Anti-Ad Fiber Knob x Anti-CEA Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL Ad Fiber Knob CEA Inquiry
BIBD-H232 Recombinant Human Anti-CD28 x Human Anti-CD40 Bispecific Antibody (Bibody) Human Bibody CD28 CD40 Inquiry
BIBD-056 Recombinant Anti-CD28 x Anti-CD40 Bispecific Antibody (Bibody) Human Bibody CD28 CD40 Inquiry
BIBD-005 Recombinant Anti-Ad Fiber Knob x Anti-ITGAV Bispecific Antibody (Bibody) Human Bibody Ad Fiber Knob ITGAV Inquiry
BIBD-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (Bibody) Human Bibody Ad Fiber Knob EPCAM Inquiry
BIBD-003 Recombinant Anti-Ad Fiber Knob x Anti-CEA Bispecific Antibody (Bibody) Human Bibody Ad Fiber Knob CEA Inquiry
FABFV-H232 Recombinant Human Anti-CD28 x Human Anti-CD40 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD28 CD40 Inquiry
FABFV-056 Recombinant Anti-CD28 x Anti-CD40 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD28 CD40 Inquiry
FABFV-005 Recombinant Anti-Ad Fiber Knob x Anti-ITGAV Bispecific Antibody (Fab-Fv) Human Fab-Fv Ad Fiber Knob ITGAV Inquiry
FABFV-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (Fab-Fv) Human Fab-Fv Ad Fiber Knob EPCAM Inquiry
FABFV-003 Recombinant Anti-Ad Fiber Knob x Anti-CEA Bispecific Antibody (Fab-Fv) Human Fab-Fv Ad Fiber Knob CEA Inquiry
MiniB-H232 Recombinant Human Anti-CD28 x Human Anti-CD40 Bispecific Antibody (Minibody) Human Minibody CD28 CD40 Inquiry
MiniB-056 Recombinant Anti-CD28 x Anti-CD40 Bispecific Antibody (Minibody) Human Minibody CD28 CD40 Inquiry
MiniB-005 Recombinant Anti-Ad Fiber Knob x Anti-ITGAV Bispecific Antibody (Minibody) Human Minibody Ad Fiber Knob ITGAV Inquiry
MiniB-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (Minibody) Human Minibody Ad Fiber Knob EPCAM Inquiry
MiniB-003 Recombinant Anti-Ad Fiber Knob x Anti-CEA Bispecific Antibody (Minibody) Human Minibody Ad Fiber Knob CEA Inquiry
SCTB-H127 Recombinant Human Anti-CD40 x Human Anti-CD28 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD28 CD40 Inquiry
SCDB-H230 Recombinant Human Anti-CD28 x Anti-CD40 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD28 CD40 Inquiry
FABIG-H230 Recombinant Human Anti-CD28 x Anti-CD40 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD28 CD40 Inquiry
TRIB-H232 Recombinant Human Anti-CD28 x Anti-CD40 Bispecific Antibody (Triple Body) Human Triple Body CD28 CD40 Inquiry
BSIG-H230 Human Anti-CD28 x Anti-CD40 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD28 CD40 Inquiry
CROSSAB-H230 Recombinant Human Anti-CD28 x Anti-CD40 Bispecific Antibody (CrossMab) Human CrossMab CD28 CD40 Inquiry
IGFV-H230 Recombinant Human Anti-CD28 x Anti-CD40 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD28 CD40 Inquiry
BSDB-H230 Recombinant Human Anti-CD28 x Anti-CD40 Bispecific Antibody (Diabody) Human Diabody CD28 CD40 Inquiry
BSFAB-H230 Recombinant Human Anti-CD28 x Anti-CD40 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD28 CD40 Inquiry
BSFV-H230 Recombinant Human Anti-CD28 x Anti-CD40 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD28 CD40 Inquiry
SCTB-028 Recombinant Anti-CD40 x Anti-CD28 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD28 CD40 Inquiry
SCDB-056 Recombinant Anti-CD28 x Anti-CD40 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD28 CD40 Inquiry
SCDB-005 Recombinant Anti-Ad Fiber Knob x Anti-ITGAV Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody Ad Fiber Knob ITGAV Inquiry
SCDB-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody Ad Fiber Knob EPCAM Inquiry
SCDB-003 Recombinant Anti-Ad Fiber Knob x Anti-CEA Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody Ad Fiber Knob CEA Inquiry
FABIG-056 Recombinant Anti-CD28 x Anti-CD40 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD28 CD40 Inquiry
FABIG-005 Recombinant Anti-Ad Fiber Knob x Anti-ITGAV Bispecific Antibody (Fab-IgG) Human Fab-IgG Ad Fiber Knob ITGAV Inquiry
FABIG-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (Fab-IgG) Human Fab-IgG Ad Fiber Knob EPCAM Inquiry
FABIG-003 Recombinant Anti-Ad Fiber Knob x Anti-CEA Bispecific Antibody (Fab-IgG) Human Fab-IgG Ad Fiber Knob CEA Inquiry
TRIB-056 Recombinant Anti-CD28 x Anti-CD40 Bispecific Antibody (Triple Body) Human Triple Body CD28 CD40 Inquiry
TRIB-005 Recombinant Anti-Ad Fiber Knob x Anti-ITGAV Bispecific Antibody (Triple Body) Human Triple Body Ad Fiber Knob ITGAV Inquiry
TRIB-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (Triple Body) Human Triple Body Ad Fiber Knob EPCAM Inquiry
TRIB-003 Recombinant Anti-Ad Fiber Knob x Anti-CEA Bispecific Antibody (Triple Body) Human Triple Body Ad Fiber Knob CEA Inquiry
BSIG-056 Anti-CD28 x Anti-CD40 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD28 CD40 Inquiry
BSIG-005 Anti-Ad Fiber Knob x Anti-ITGAV Bispecific Antibody (IgG-IgG) Human IgG-IgG Ad Fiber Knob ITGAV Inquiry
BSIG-004 Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (IgG-IgG) Human IgG-IgG Ad Fiber Knob EPCAM Inquiry
BSIG-003 Anti-Ad Fiber Knob x Anti-CEA Bispecific Antibody (IgG-IgG) Human IgG-IgG Ad Fiber Knob CEA Inquiry
CROSSAB-056 Recombinant Anti-CD28 x Anti-CD40 Bispecific Antibody (CrossMab) Human CrossMab CD28 CD40 Inquiry
CROSSAB-005 Recombinant Anti-Ad Fiber Knob x Anti-ITGAV Bispecific Antibody (CrossMab) Human CrossMab Ad Fiber Knob ITGAV Inquiry
CROSSAB-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (CrossMab) Human CrossMab Ad Fiber Knob EPCAM Inquiry
CROSSAB-003 Recombinant Anti-Ad Fiber Knob x Anti-CEA Bispecific Antibody (CrossMab) Human CrossMab Ad Fiber Knob CEA Inquiry
IGFV-056 Recombinant Anti-CD28 x Anti-CD40 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD28 CD40 Inquiry
IGFV-005 Recombinant Anti-Ad Fiber Knob x Anti-ITGAV Bispecific Antibody (IgG-scFv) Human IgG-scFv Ad Fiber Knob ITGAV Inquiry
IGFV-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (IgG-scFv) Human IgG-scFv Ad Fiber Knob EPCAM Inquiry
IGFV-003 Recombinant Anti-Ad Fiber Knob x Anti-CEA Bispecific Antibody (IgG-scFv) Human IgG-scFv Ad Fiber Knob CEA Inquiry
BSDB-056 Recombinant Anti-CD28 x Anti-CD40 Bispecific Antibody (Diabody) Human Diabody CD28 CD40 Inquiry
BSDB-005 Recombinant Anti-Ad Fiber Knob x Anti-ITGAV Bispecific Antibody (Diabody) Human Diabody Ad Fiber Knob ITGAV Inquiry
BSDB-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (Diabody) Human Diabody Ad Fiber Knob EPCAM Inquiry
BSDB-003 Recombinant Anti-Ad Fiber Knob x Anti-CEA Bispecific Antibody (Diabody) Human Diabody Ad Fiber Knob CEA Inquiry
BSFAB-056 Recombinant Anti-CD28 x Anti-CD40 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD28 CD40 Inquiry
BSFAB-005 Recombinant Anti-Ad Fiber Knob x Anti-ITGAV Bispecific Antibody (Tandem Fab) Human Tandem Fab Ad Fiber Knob ITGAV Inquiry
BSFAB-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (Tandem Fab) Human Tandem Fab Ad Fiber Knob EPCAM Inquiry
BSFAB-003 Recombinant Anti-Ad Fiber Knob x Anti-CEA Bispecific Antibody (Tandem Fab) Human Tandem Fab Ad Fiber Knob CEA Inquiry
BSFV-056 Recombinant Anti-CD28 x Anti-CD40 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD28 CD40 Inquiry
BSFV-005 Recombinant Anti-Ad Fiber Knob x Anti-ITGAV Bispecific Antibody (Tandem scFv) Human Tandem scFv Ad Fiber Knob ITGAV Inquiry
BSFV-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (Tandem scFv) Human Tandem scFv Ad Fiber Knob EPCAM Inquiry
BSFV-003 Recombinant Anti-Ad Fiber Knob x Anti-CEA Bispecific Antibody (Tandem scFv) Human Tandem scFv Ad Fiber Knob CEA Inquiry

Background

Ad fiber knob is the receptor-interacting domain of the fiber protein found on the surface of adenoviruses. The binding of the fiber knob to a receptor initiates adenovirus entry into the cell. CD40 is a receptor found on immune cells that is required for a wide range of immunological and inflammatory responses. The anti-Ad fiber knob×anti-CD40 bispecific antibody (BsAb) is designed to recognize and bind to both Ad fiber knob and CD40, triggering immune responses such as the production of cytokines and activation of T cells, leading to enhanced antiviral responses and limited infection severity. The application fields of this BsAb include the research of viral infection therapy caused by adenoviruses. In addition, this BsAb may have potential applications in cancer immunotherapy, as CD40 activation can enhance immune responses against tumors.

Fig.1 Ad fiber knob and CD40 structures. (Krasnykh, et al., 2000; https://commons.wikimedia.org/wiki/File:Protein_CD40_PDB_1CDF.png) Fig.1 Structures of Ad fiber knob and CD40.1,2

References

  1. Krasnykh, Victor, et al. "Advanced generation adenoviral vectors possess augmented gene transfer efficiency based upon coxsackie adenovirus receptor-independent cellular entry capacity." Cancer Research 60.24 (2000): 6784-6787.
  2. From Wikipedia: By Pleiotrope - Own work, Public Domain, https://commons.wikimedia.org/wiki/File:Protein_CD40_PDB_1CDF.png
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