Recombinant Human Anti-Ad Fiber Knob x Anti-CD40 Bispecific Antibody (scFv-CH3) (BSFC-002)

Recombinant Anti-Ad fiber knob x Anti-CD40 Bispecific Antibody (scFv-CH3) contains two chains. The anti-Ad fiber knob scFv is fused to the Knob-CH3 domain via a hinge region and the same as the anti-CD40 scFv to the Hole-CH3 domain, or vice versa. The KIH CH3 domains can facilitate to form a heterodimer and this bivalent binding leads to improvement in avidity. This BsAb can retarget of adenoviral vectors to tumour cells. It can be used in cancer gene therapy to transfer a therapeutic gene into tumour cells aiming at selective and efficient cell killing.

Datasheet INQUIRY

Specifications

Targets

Ad Fiber Knob & CD40

Type

scFv-based Bispecific Fragments

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Acute myeloid leukaemic (AML)

Targets

Target 1

Ad Fiber Knob

Alternative Names

Ad fiber knob; Adenovirus fiber knob; adenovirus fiber protein; knob domain of Ad fiber

Target 2

CD40

Gene ID

958

UniProt ID

P25942

Alternative Names

CD40; CD40 molecule; p50; Bp50; CDW40; TNFRSF5

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Human Anti-Ad Fiber Knob x Anti-CD40 Bispecific Antibody (scFv-CH3) (CAT#: BSFC-002)

Specifications

Targets

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