shRNA Adenovirus Serotype 5 (ΔE1/E3), pU6-(RTBDN-shRNA-Seq2)(CAT#: AdV-SI0374WQ)
This product is a RTBDN-shRNA encoding AdV, which is based on AdV-5 serotype with EIB-55K gene deleted. The protein encoded by RTBDN gene is preferentially expressed in the retina and may play a role in binding retinoids and other carotenoids as it shares homology with riboflavin binding proteins. The expression of RTBDN-shRNA leads to target gene silencing and this product can be used in gene therapy research and development.
Specifications | |
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Family | Adenoviridae |
Species | Adenovirus |
Serotype | HAdV-5 |
Backbone | AdV-5 (ΔE1/E3) |
Tropism | Both nondividing and dividing cells |
Insert | RTBDN-shRNA-Seq2 |
Related Target/Protein | RTBDN |
Region | CDS |
TargetSeq | GAATGCGAATCCTTCCTGGAA |
NCBI RefSeq | NM_031429 |
Titer | >1*10^10 GC/mL |
Related Diseases | Eye disease |