Aided by in-house scientists and advanced technology platforms, Creative Biolabs has launched comprehensive services related brain-immune-gut-based integrative studies for global clients to speed up the project’s development.

Background of Brain-Immune-Gut Axis

The brain-immune-gut axis has been a hot topic of research during the past decade. And the interactions between the gut microbiota, peripheral immune system, and central nervous system (CNS) play crucial roles in the maintaining of host health. Which covers several biological networks involving the immune system, neuroendocrine system, neural network, and metabolic pathways.

Specifically, identifying microbial derivatives such as microbe-associated molecular patterns (MAMPs), as well as microbial metabolic by-products (short-chain fatty acids, SCFAs) can activate different immune pathways of the host. Then, the microbiota and immune system can regulate neurophysiology independently or cooperatively. Conversely, biochemical alterations in the central nervous system could also contribute to changes in microbial composition and immune responses by the HPA axis. Altogether, these items showed bidirectional communication between the microbiome, the immune system, and the central nervous system. Future studies of these bidirectional interactions will also inform the development of new therapeutic strategies for the treatment of neurological disorders.

Fig.1 Crosstalk between the microbiota, immune system, and CNS. (Salvo-Romero, 2020)

Our Custom Services

To better study brain-immune-gut interaction, Creative Biolabs has developed and optimized a series of functional assay platforms to provide relevant experiments, including but not limited to:

We are proud to offer integrative research portfolio services for global customers to meet your research needs. Our services are characterized by:

• Flexible assay formats to meet diverse project needs;
• An excellent expert team for providing real-time technical guidance.
• Advanced and optimized assay platform to facilitate the data output.
• Customize experiment types according to customer needs to facilitate project progress.

Creative Biolabs offers high-quality assay portfolio services related to brain-immune-gut-based integrative study, which will help our clients shorten the research journey. For more detailed information, please feel free to contact us or directly send us an inquiry.

References

1. Salvo-Romero, E.; et al. Microbiota-immune interactions: From gut to brain. LymphoSign Journal. 2020, 7(1): 1-23.
2. Fung, T.C.; et al. Interactions between the microbiota, immune and nervous systems in health and disease. Nature neuroscience. 2017, 20(2): 145-55.

For Research Use Only | Not For Clinical Use