What Is Gut-Brain Axis?Our ServicesWhy Choose Us?Related Services
Microbiota-immune interactionsvia the gut-brain axis (GBA) is one of the hotspots in research, which has been greatly benefitted by the research advances in the complex bidirectional communications between the gut microbiota, the immune system and the central nervous system (CNS), which forms a complicated neuroimmune homeostasis regulation network mediated by derma–gut microbiota interactions for gut-brain immune homeostasis, including microbiota-based host neuroimmune modulation, gut neuroimmune interaction, and consequently gut neuro-psych immunology. Based on our longstanding experience in immunology and microbiota research, Creative Biolabs is enabled to screen therapeutic strategies targeting the GBA to address complex diseases involving the brain, nerves and behavior.
Background of Microbiota-Immune Interactions
The microbiome-immune interactions between gut and brain have emerged as a hot zone among many scientists throughout the past decade, and the microbiota-gut-brain axis has become a true research area, while more and more studies about it have been published to address its possible roles in memory, learning, stress, neurodevelopmental and neurodegenerative disorders.
Gut-Brain Axis
The gut-brain axis (GBA) is a bidirectional communication regulatory system that connects the central nervous system (CNS) to the intestine through the gut microbiota, thereby shaping immune responses that, in turn, set the stage for CNS activities. The gut microbiota influences the function of immune cells, such as Tregs and TLRs, and regulates the immune activity in both the intestine and the brain. The dysbiosis of the gut microbiota can lead to malfunction of immune cells and a poor blood-brain barrier, which, in turn, leads to neuroinflammation, which appears to be a common feature among diseases of the brain, such as depression, obesity, autism and some neurodegenerative diseases, including Alzheimer's and Parkinson's. That is how the communication along the gut-brain axis through the microbiota appears to maintain immune and neural health.
Fig.1 Pathways of Microbiota-Gut-Brain Communication.1
Service at Creative Biolabs
Creative Biolabs offers tailored in vitro and in vivo platforms for assay development, supporting diverse research needs in immuno-oncology, microbiome research, and gut-brain axis studies. With end-to-end solutions, we assist clients in advancing their biopharmaceutical pipelines by integrating custom assays, microbiome profiling, immune response evaluation, and drug screening.
Gut-Brain Axis Assays
Measurement of neurotransmitters and SCFAs relevant to cognition.
Advanced NGS-based profiling and real-time Treg/Th17 tracking for immune modulation studies.
Drug Screening Platforms
High-throughput systems for screening probiotics, small molecules, and microbial interventions.
Advantages of Our Custom Assay Service
Exceptional Analytical Performance
High reproducibility and fast, data-driven insights to accelerate R&D.
Efficient and Scalable Solutions
Optimized reagent use and quick assay turnaround.
Broad Expertise and Innovation
Decades of experience backed by cutting-edge tools like CRISPR editing and multi-omics.
Collaborative and Personalized Service
Dedicated project management for seamless delivery from design to execution.
Creative Biolabs combines precision, efficiency, and innovation to meet the complex needs of immuno-oncology and microbiota research. Our tailored services and scientific expertise enable clients to drive therapeutic breakthroughs efficiently and effectively. Scientists at Creative Biolabs are dedicated to combining years of valuable experience to help our clients shorten the project journey. For more detailed information, please feel free to contact us or directly send us an inquiry.
Reference
Zajkowska, Izabela, et al. "Investigating the Impacts of Diet, Supplementation, Microbiota, Gut–Brain Axis on Schizophrenia: A Narrative Review." Nutrients 16.14 (2024): 2228. Distributed under Open Access license CC BY 4.0, without modification.
Fig.1 Pathways of Microbiota-Gut-Brain Communication.1
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