CAR-T Animal Model
Cellular therapy is to inject cellular materials into a patient for therapeutic purpose. Gene therapy is to manipulate or modify the expression of a gene or alter the biological properties of cells for therapeutic purpose. Creative Biolabs is dedicated to establishing the most appropriate animal models for the development of your CAR-T products including pharmacology services and toxicology services.
Animal Models
Creative Biolabs is dedicated to a full spectrum of preclinical services for cellular and gene therapy (CGT) products including oncolytic virus, plasmid DNA, viral vectors, bacterial vectors, human gene editing technology, patient-derived cellular gene therapy products, and stem cell derived cells, mature/functionally differentiated cells, such as T cells, NK cells and macrophage cells.
Careful selection of animal models is critical for proof-of-concept studies and pharmacologically sensitive species for CGT products that offered to anticipated clinical route of administration. For animal models with competent immune system, we can inhibit immune response via immunosuppressive agents to ensure cell survival after implantation. In addition, we offer surgically altered models as per specific requirements. Our various surgical implantation methods include intraocular, intraspinal, intracranial, intrathecal, myocardial, intracoronary, topical grafting, intraprostatic, infusion, and they can mimic clinical routes of administration which is important for program success. For detailed animal model types, please visit the following modules.
Immunological tolerance
For animal models with competent immune system, if the animal model rejects the product, we can provide different strategies to inhibit immune response to ensure cell survival after implantation.
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Immunosuppressive agents
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Gene modified immunodeficient animals
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Humanized animals
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Immune privileged site
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Combination
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Analogous animal product
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Animal model species
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Small animal models: Mouse (disease state, normal or immunodeficient), Rat (normal or immunodeficient), Guinea, Pig, Rabbit;
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Large animal models: Dog, Pig, Mini-pig, Goat Sheep, Non-human primate
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Routes of administration
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Intravenous, Intra-arterial, Intradermal, Intramuscular, Subcutaneous, Oral Intraperitoneal, Intraportal
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Considerations for Animal Models
Here are some specific considerations for animal models in the development of cellular and gene therapy products. If you are interested in any part, please contact us for a deep communication to learn how we can be involved in your project.
Considerations for animal species selection
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Biological response should be similar to humans;
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Consider anatomy, viral replication, immune tolerance, compatibility with patient delivery system;
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More than one species might be required;
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In Vivo tests to help identify ideal animal species;
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Rationale and summary part of IND submission.
Selection of animal cancer models
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Same models from basic research may benefit preclinical studies;
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Might be preferable to healthy animals to assess mechanism and safety;
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Possible identification of biomarkers to monitor clinical trials;
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Ability to access the anatomic site for administration;
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Ability to deliver specific dose to target sites;
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Immunodeficient animals for long term assessment.
Animal model for gene therapy products
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Vector permissive (or sensitive);
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Biologically responsive to the transgene of interest.
With high quality commercial breeding facilities, genetic standards and rigorous biosecurity, and relative research support services, Creative Biolabs is dedicated to providing you with specific animal models to fit your CGT product discovery and development. Please contact us for detailed information and deep communication about your program.
For Research Use Only | Not For Clinical Use
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