To test the cancer immunotherapies in a functional immune system in preclinical tests, syngeneic mouse models act as one of the most appropriate models to evaluate your immunotherapies and fast-track in vivo screening. Creative Biolabs is dedicated to providing a comprehensive service of syngeneic animal models to facilitate your drug candidate evaluation.
Immunotherapies in Syngeneic Models
Cancer immunotherapies are designed as an artificial way to work in conjunction with the patients’ natural
immune system to fight cancer. The traditional xenograft models lack correlation due to the
immunocompromised status of animal models. As a powerful approach, syngeneic models can effectively
evaluate the performance of cancer immunotherapies in the presence of a complete immune system.
Syngeneic Mouse Models
Creative Biolabs provides a wide range of syngeneic mouse models with well characterized responses to known immunotherapies including immune checkpoint inhibitors, immune profiling and genetic evaluations. Empowered with a broad portfolio of syngeneic models which can respond to known immunotherapies as well as CDX, PDX and humanized models, Creative Biolabs is your ideal partner to advance your cancer immunotherapy discovery and development pipeline. We offer a collection of over 30 syngeneic mouse models available for your efficacy studies, covering a variety of cancer types.
|
Type
|
Cell Line
|
|
Bladder
|
MBT-2
|
|
Brain
|
GL261
|
|
Breast
|
4T1, EMT-6, JC
EMT-6-BRCA1(−/−), EMT-6-BRCA1(+/−),
4T1-BRCA1(+/−)
|
|
Colon
|
Colon26, CT26, WT
|
|
Fibrosarcoma
|
WEHI 164
|
|
Gastric
|
mfc
|
|
Glioma
|
GL261 Red-Fluc
|
|
Hepatoma
|
Yoshida
|
|
Kidney
|
Renca
|
|
Leukemia
|
C1498, L1210, P388
|
|
Liver
|
H22, Hepa 1-6
|
|
Lung
|
KLN 205, Lewis Lung, Madison109, LL/2(LLC1)
|
|
Lymphoma
|
A20, E.G7-OVA, L5178-R(LY-R), EL4, P388D1,
YAC-1
|
|
Mastocytoma
|
P815
|
|
Melanoma
|
B16F10, CloudmanS91, B16-BL6, B16-F0,
B16-F1
|
|
Myeloma
|
MPC-11, J558, P3X63Ag8U.1, SP2/0, FO
|
|
Neuroblastoma
|
N1E-115, Neuro-2a
|
|
Plasmacytoma
|
J558
|
|
Prostate
|
RM-1
|
|
Renal
|
Renca, RAG
|
|
Sarcoma
|
EHS, K7M2 WT
|
|
Testis
|
MLTC-1
|
Applications
-
✔ Immuno-based therapy development;
-
✔ Therapeutic effect evaluation;
-
✔ Drug and therapy development.
We provide subcutaneous, orthotopic, systemic, metastatic and other models for various cell lines. This
superior syngeneic model platform has opened up fascinating lines of investigation for cancer immunotherapy
research. Please contact us for detailed communication about
cancer type, cell line and xenograft models
to fit your program.
Highlights
To mimic the functional efficacy of immunotherapies in clinical trials, we have established a powerful platform of syngeneic models to validate candidates, evaluate in vivo efficacy and generate predictive data for novel immunotherapies.
-
✔ Work in conjunction with global leaders in preclinical immuno-oncology model development;
-
✔ Confirmed synergistic response with known checkpoint inhibitor as a reference;
-
✔ Capacity to confirm the response data of your candidates.
Our large panel of syngeneic models are well characterized as ideal models for your immunotherapy evaluation as well as combination therapies. Creative Biolabs is fully competent to be a reliable partner to design and provide syngeneic animal models for our clients. Please contact us if you want to learn how to involve us in your project. We promise to serve you always the best.
Download our brochure