Immuno-Oncology Animal Models

Due to the clinical and commercial success of novel immunotherapies such as CAR-T therapy and checkpoint inhibitors, immuno-oncology has blossomed into one of the most promising areas of cancer therapy. To address the remaining immuno-oncology questions, relevant immuno-oncology platforms are required including pre-clinical immuno-oncology animal models. Creative Biolabs has established a vast array of animal models to advance your drug discovery program.

Fig.1 Animal models for immune-oncology research. (Creative Biolabs Original)

Immuno-Oncology Animal Models

The superior IO animal model platform has opened up fascinating lines of research for cancer immunotherapy. Selecting the appropriate animal model for your program is critically important to the success of your research. Our animal model platform allows you to get the most appropriate model before making a commitment. Whether you are conducting a new research protocol, or fine-tuning a pilot study, or simply exploring another opportunity to switch to a new immune-oncology animal model, our team can help you make the right choice. Please visit the followings to check your desired models. If you are interested in any other models, please contact us for a customized solution.

Syngeneic models

Humanized models

Patient Derived Xenograft models (PDX models)

Cell Line Derived Xenograft models (CDX models)

Database of CDX models

Other Animal Models

We also provide other animal models to meet your specific demands, which allows you to assess the compatibility and quality of our animal models before making commitments.

▶ Immunodeficient models

BALB/c Nude or B6 Nude (which is T cell deficient)
Severe combined immunodeficiency models (SCID)
NOD SCID (which is T and B cell deficient)
NOG or NSG mice (which is T, B and NK cell deficient)

▶ Immunocompetent models

▶ Cryopreserved oncology models

▶ Chemical-induced cancer model

Our Immuno-Oncology Animal Model Services

To obtain the most appropriate animal model for pre-clinical testing to simulate trials, validate candidates, evaluate in vivo efficacy and produce predictive data of novel immunotherapies, we offer a comprehensive set of services including:

Xenotransplantation study design;
Selection of appropriate cancer model/cell line;
Host animal selection;
Subcutaneous or orthotopic or other xenografting;
Observation of experimental subjects;
Post-experiment analysis including serum collection and histology.

Our in vivo pre-clinical testing can seamlessly establish animal models in vivo, carry out research and read out endpoints to determine the mechanism of action, PD/PK profile, toxicology in animal models. Creative Biolabs aims to construct an almost complete immuno-oncology animal model platform to facilitate all immunotherapies research. Please contact us if you want to learn more. We are committed to providing you with the best service.