Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsMonoclonal antibodies have gradually played a pivotal part in the field of biomedicine research. Monoclonal antibodies are characterized by high sensitivity, high specificity, high efficiency, low toxicity, and others. They play an important role in the fields of disease diagnosis and disease treatment. A specific lgM antibody exists in cattle that has an extraordinarily long CDR H3 region, with the longest CDR H3 being 75 amino acids long. Based on our rich field experience and advanced antibody preparation platform, Creative Biolabs provides comprehensive antibody discovery services to support monoclonal bovine antibody production.
Currently, monoclonal antibodies are widely used in clinical treatment. In disease diagnosis, monoclonal antibodies can identify pathogens and accurately diagnose infectious diseases. It is also capable of detecting lymphocyte surface molecules to distinguish lymphocytes at different stages of differentiation and is used to identify lymphocytes. Monoclonal antibodies can also be used for tumor diagnosis and typing. Some monoclonal antibodies have the property of accumulating at the tumor site and therefore can be used for tumor diagnosis. Clinical studies have shown that monoclonal antibodies have a unique role in the treatment of many cancers, especially refractory cancers, and they are increasingly used in the treatment of immunologic diseases, such as rheumatoid arthritis and allogeneic rejection, and viral infections.
Bovine monoclonal antibodies offer unique advantages in the study of antigenic structure. The ultra-long CDR3 loop of bovine antibodies is the longest CDR3 loop (50–75 amino acids) of any other species, facilitating the recognition of deeply embedded epitopes. Structural and deep sequencing analyses indicate that the extra-long CDR3 ring contains an even number of cysteines, forming a unique structure in which the cysteines are involved in the formation of a diverse disulfide bonding "knob" structural domain supported by a β-strand "stalk". This long CDR3 loop allows bovine antibodies to more effectively attack a wide range of bacterial and viral targets or capture molecular targets, especially antigens that are not recognized by conventional antibodies, such as GPCRs.
In treating COVID-19 infections, researchers have found that by genetically modifying cows, some of their immune cells can be made to carry DNA. This DNA can help people make antibodies to deal with the virus, including the spike (S) proteins that are on the surface of the COVID-19 virus. The process involves first vaccinating the cow with a vaccine that contains a portion of the virus' genomic DNA, which protects the cow's immune system against the virus. The cattle are then injected with the spike protein containing the COVID-19 virus, which is essential for the virus to enter the cells.
In this process, cows act as huge bioreactors for antibody preparation. In fact, cows are a great antibody factory. Not only because they have more blood, but they also have more antibodies per milliliter of blood—twice as many as human blood. Therefore, monoclonal bovine antibodies have great research potential. More efficient preparation of monoclonal bovine antibodies can be realized by phage display library construction. While the immune antibody libraries are subjected to the selective pressure of immunization, the abundance of immune antibody libraries specific for the corresponding immunogens is much higher than that of other non-specific antibodies. At the same time, the immune antibody library can realize the screening of functional antibodies and their genes against immunogens from a library with a small library capacity (105).
Creative Biolabs has a wealth of knowledge and experience in monoclonal antibody discovery. We would be happy to share with you our knowledge and experience related to monoclonal bovine antibody discovery.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
