- This product is an antibody that was generated by immunizing mouse against human Bax peptide (a.a. 3-16). It is used only in in vitro assays.
Detailed Product Description
- Introduction: BAX is a members of the Bcl-2 Family and plays an important role in regulation of apoptosis. Whereas Bcl-2 is commonly regarded as an anti-apoptotic protein, BAX is considered to have a pro-apoptotic function. Regulation of apoptosis is supposed to involve both homo- and heterodimerization of different isoforms of BAX and Bcl-2. The Bax gene encodes different isoforms including Bax alpha (21 kDa) and Bax beta (24 kDa), whereas both isoforms contain the BH1, BH2 and BH3 domains, Bax beta has a unique carboxyl terminus and does not contain a hydrophobic transmembrane domain. Bcl-2 is also expressed in different Isoforms. Bcl-2 beta differs in the 3' UTR and coding region compared to variant alpha. Bcl-2 beta is shorter (22 kDa) and has a distinct C-terminus compared to Bcl-2 alpha (26 kDa). BAX is a member of the BCL-2 family of proteins, which function as regulators of apoptosis. Overexpression of BAX functions to promote cell death. BAX can form homodimers and is also able to heterodimerize with other BCL-2 related proteins.
- Conjugate: None
- Antibody Isotype: IgG1
- Applications: Flow Cytometry
Technical Specifications
- Host Species: Mouse
- Species Reactivity: Bovine; Human; Monkey
- Immunogen: Human Bax peptide (a.a. 3-16)
Product Property
- Format: Liquid
- Concentration: 0.1 mg/mL
- Buffer: Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added
- Storage: Store at 4⁰C.
Target Information
- Target: Bax
- Clone: DO-9
- Clonality: Monoclonal
- Alternative Names: Apoptosis regulator BAX; Bax zeta; Baxdelta2G9; Baxdelta2G9omega; Baxdelta2omega; Bcl-2-like protein 4; BCL2 associated X protein; BCL2-associated X protein omega; Bcl2-L-4
- Entrez Gene ID: 581
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