DPP4 Polyclonal Antibody (NHP-AB330)

• This product is an antibody that was generated by immunizing rabbit against a peptide located near the internal domain of DPP4 (Human). It is used only in in vitro assays.

Detailed Product Description

• Introduction: DPP4, adenosine deaminase (ADA) binding protein) is a homodimeric atypical serine protease belonging to the prolyl oligopeptidase family. DPP4 is expressed on lymphocyte cells and is upregulated during T-cell activation. DPP4 is also expressed on activated B cells and natural killer cells and abundantly on epithelia. DPP4 is implicated in a variety of biological functions including T-cell activation, cell adhesion with extracellular matrix such as fibronectin or collagens, and in HIV infection. Cross-linking of DPP4 using this antibody dramatically enhances the anti CD3-induced IL - 2 production. DPP4 identical to adenosine deaminase complexing protein-2, and to the T-cell activation antigen DPP4. Further, DPP4 is an intrinsic membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. Alterations in DPP4 peptidase activity are characteristic of malignant transformation, and the enzymatic activity increases dramatically with tumor grade and severity. DPP4 is expressed in various blood cell types, but also in cells that are histogenetically related to activated fibroblasts. Alterations in DPP4 density have been reported on circulating monocytes and CD4+ T cells during rheumatoid arthritis and systemic lupus erythematosus.
• Conjugate: None
• Applications: IHC-P

Technical Specifications

• Host Species: Rabbit
• Species Reactivity: Gibbon; Gorilla; Human; Monkey; Orangutan
• Immunogen: A peptide located near the internal domain of DPP4 (Human)

Product Property

• Purification: Immunoaffinity Chromatography
• Format: Liquid
• Concentration: 1 mg/mL
• Buffer: PBS, 0.1% sodium azide.
• Storage: Short term: 4˚C. Long term: Store at -20˚C.

Target Information

• Clonality: Polyclonal
• Alternative Names: ADABP; ADCP-2; Adenosine deaminase complexing protein 2; CD26; Dipeptidyl peptidase 4; Dipeptidyl peptidase 4 membrane form; Dipeptidyl peptidase 4 soluble form; Dipeptidyl peptidase IV; Dipeptidyl peptidase IV membrane form; Dipeptidyl peptidase IV soluble form; dipeptidyl-peptidase 4; dipeptidylpeptidase 4; dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2); DPP IV; DPP-IV; T-cell activation antigen CD26; TP103
• Entrez Gene ID: 1803