GPR68 Polyclonal Antibody (NHP-AB363)

• This product is an antibody that was generated by immunizing rabbit against a peptide located in the 1st extracellular domain of GPR68 (Human). It is used only in in vitro assays.

Detailed Product Description

• Introduction: GPR68, also known as OGR1 - ovarian cancer G-protein coupled receptor 1, is a proton-sensing receptor involved in pH homeostasis. It represents an osteoblastic pH sensor regulating the cell-mediated response to acidosis in bone. GPR68 mediates its action by association with G proteins that stimulate inositol phosphate (IP) production or CA2+ mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Also found to serve as a tumor suppressor in prostate cancer. Mutations to the gene result in amelogenesis imperfecta, hypomaturation type 2A6.
• Conjugate: None
• Applications: ELISA; IHC

Technical Specifications

• Host Species: Rabbit
• Species Reactivity: Gibbon; Gorilla; Human; Monkey; Rat
• Immunogen: A peptide located in the 1st extracellular domain of GPR68 (Human)

Product Property

• Purification: Immunoaffinity Chromatography
• Format: Liquid
• Concentration: 1 mg/mL
• Buffer: PBS, 0.1% sodium azide.
• Storage: Short term: 4˚C. Long term: Store at -20˚C.

Target Information

• Clonality: Polyclonal
• Alternative Names: Brgr1; Brgrb; G-protein coupled receptor 68; GPR12A; OGR-1; ovarian cancer G protein-coupled receptor, 1; Ovarian cancer G-protein coupled receptor 1; Sphingosylphosphorylcholine receptor
• Entrez Gene ID: 8111