PDE8B Polyclonal Antibody (NHP-AB417)

• This product is an antibody that was generated by immunizing rabbit against human leukocytes. It is used only in in vitro assays.

Detailed Product Description

• Introduction: Cyclic nucleotide phosphodiesterases (PDEs) catalyze hydrolysis of the 5-prime,3-prime-cyclic nucleotides cAMP and cGMP to the corresponding nucleoside 5-prime-monophosphates. Mammalian PDEs have been grouped into several families based on substrate affinities, inhibitor sensitivities, mode of regulation, and amino acid sequence homologies. The PDE8 family contains high-affinity cAMP-specific, IBMX (3-isobutyl-1-methyl-xanthine)-insensitive PDEs, such as PDE8B. All PDEs share a conserved C-terminal catalytic region and a variable N-terminal domain that presumably accounts for the distinctive regulatory properties unique to the individual families.
• Conjugate: None
• Applications: IHC

Technical Specifications

• Host Species: Rabbit
• Species Reactivity: Gibbon; Gorilla; Human; Monkey
• Immunogen: A peptide located near the internal domain of PDE8B (Human)

Product Property

• Purification: Immunoaffinity Chromatography
• Format: Liquid
• Concentration: 0.3 mg/mL
• Buffer: PBS, 0.1% sodium azide
• Storage: Short term: 4˚C. Long term: Store at -20˚C.

Target Information

• Clonality: Polyclonal
• Alternative Names: 3',5' cyclic nucleotide phosphodiesterase 8B; Cell proliferation-inducing gene 22 protein; FLJ11212; High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B; HsPDE8B
• Entrez Gene ID: 8622