PPP1R1A Polyclonal Antibody (NHP-AB429)

• This product is an antibody that was generated by immunizing rabbit against a portion of amino acids 50-100 of human IPP-1. It is used only in in vitro assays.

Detailed Product Description

• Introduction: PPP1R1A, also designated inhibitor of protein phospha-tase 1, IPP-1 and I-1, plays a role in regulating the phosphorylation of other proteins, and is itself phosphorylated by a cyclic AMP-dependent protein kinase at Threonine 35. In addition, the proline-directed kinases Cdk1, Cdk5, and mitogen-activated protein kinase (MAPK) mediate in vitro phosphorylation of PPP1R1A at the phylogenetically conserved position Serine 67. In striatal tissues, glutamate-dependent regulation of N-methyl-d-aspartic acid-type channels influences PPP1R1A phosphorylation at Ser 67. The localization and expression of PPP1R1A suggests that it may play discrete roles in certain regions and developing stages of the brain, independent of the regulation of protein phosphatase type 1 (PP-1). PP-1 binds to both phosphorylated and dephosphorylated PPP1R1A. Conversion of PP-1 to a Mn++-dependent state appears to play a role in its regulation by PPP1R1A. PPP1R1A attenuates the activity of glycogen phosphorylase and is thought to be important in the hormonal control of glycogen metabolism.
• Conjugate: None
• Applications: IHC; WB

Technical Specifications

• Host Species: Rabbit
• Species Reactivity: Bovine; Chimpanzee; Dog; Horse; Human; Monkey; Mouse; Rat; Xenopus
• Immunogen: A portion of amino acids 50-100 of human IPP-1

Product Property

• Purification: Immunoaffinity Chromatography
• Format: Liquid
• Buffer: PBS, 0.2% gelatin, 0.05% sodium azide
• Storage: Store at -20⁰C. Avoid freez-thaw cycles.

Target Information

• Clonality: Polyclonal
• Alternative Names: I-1; inhibitor-1; IPP-1; PP1 inhibitor 1; Protein phosphatase 1 regulatory subunit 1A; protein phosphatase 1, regulatory (inhibitor) subunit 1A; Protein phosphatase inhibitor 1; protein phosphatase inhibitor-1
• Entrez Gene ID: 5502