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Anti-TPBG (clone A1)-hydroxyl amino PEG-MMAD ADC (CAT#: ADC-W-312)

This ADC product is comprised of an anti-TPBG monoclonal antibody (clone A1) conjugated via a hydroxyl amino PEG linker to MMAD. The MMAD is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, MMAD binds to tubulins, interrupts microtubule dynamics, and subsequently, induces cell death.

  • Product Information
  • ADC Target
  • ADC Antibody
  • ADC Linker
  • ADC payload drug
  • Antibody clone #
  • A1
  • Name
  • TPBG
  • Alternative Names
  • M6P1; TPBGAG; WAIF1; TPBG oncofetal antigen; TPBG oncotrophoblast glycoprotein; wnt-activated inhibitory factor 1; TPBG oncofetal trophoblast glycoprotein;
  • Target Entrez Gene ID
  • 7162
  • Overview
  • This gene encodes a leucine-rich transmembrane glycoprotein that may be involved in cell adhesion. The encoded protein is an oncofetal antigen that is specific to trophoblast cells. In adults this protein is highly expressed in many tumor cells and is associated with poor clinical outcome in numerous cancers. Alternate splicing in the 5 UTR results in multiple transcript variants that encode the same protein.
  • Overview
  • Humanized Anti-TPBG antibody, clone # A1
  • Clone #
  • A1
  • Species Reactivity
  • Human
  • Name
  • hydroxyl amino PEG linker
  • Description
  • Polyethylene glycol (PEG) is a particularly attractive as a linker for conjugation. The specific characteristics of PEG moieties relevant to pharmaceutical applications include: Water solubility; Lack of toxicity; Low immunogenicity; Well defined chain lengths and molecular weights.
  • Name
  • MMAD (monomethyl auristatin D)
  • Description
  • Derived from Auristatin,are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

For Research Use Only. NOT FOR CLINICAL USE.

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CAMouse™-Fully Human Antibody Generation Platform
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