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- Anti-TPBG (clone A1)-SMCC-DMA ADC
Anti-TPBG (clone A1)-SMCC-DMA ADC (CAT#: ADC-W-005)
This ADC product is comprised of an anti-TPBG monoclonal antibody (clone A1) conjugated via a SMCC linker to DMA. The DMA is targeted to TPBG-positive cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis.
- Product Information
- ADC Target
- ADC Antibody
- ADC Linker
- ADC payload drug
- Antibody clone #
- A1
- Name
- TPBG
- Alternative Names
- M6P1; TPBGAG; WAIF1; TPBG oncofetal antigen; TPBG oncotrophoblast glycoprotein; wnt-activated inhibitory factor 1; TPBG oncofetal trophoblast glycoprotein;
- Target Entrez Gene ID
- 7162
- Target UniProt ID
- Q13641
- Overview
- This gene encodes a leucine-rich transmembrane glycoprotein that may be involved in cell adhesion. The encoded protein is an oncofetal antigen that is specific to trophoblast cells. In adults this protein is highly expressed in many tumor cells and is associated with poor clinical outcome in numerous cancers. Alternate splicing in the 5 UTR results in multiple transcript variants that encode the same protein.
- Overview
- Humanized Anti-TPBG IgG1 antibody, clone # A1
- Clone #
- A1
- Species Reactivity
- Human
- Name
- SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
- Description
- Disulfide Linkers, are extensively exploited as a chemically labile linkage. Since the release of disulfide-linked drugs requires a cytoplasmic thiol cofactor, such as glutathione (GSH). Disulfides maintain stable at physiological pH and only when ADCs are internalized inside cells, the cytosol provides reducing environment including intracellular enzyme protein disulfide isomerase, or similar enzymes, drugs can be released.
- Name
- DMA (dimethylacetamide)
For Research Use Only. NOT FOR CLINICAL USE.
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Quick Links
Other Products
Same Target
Same Linker
| CAT# | Product Name | Linker | Payload |
| ADC-W-162 | Anti-TPBG ( L443C)-Mc-MMAD ADC | Mc (maleimidocaproyl) | MMAD (monomethyl auristatin D) |
| ADC-W-161 | Anti-TPBG ( V422C)-Mc-MMAD ADC | Mc (maleimidocaproyl) | MMAD (monomethyl auristatin D) |
| ADC-W-165 | Anti-TPBG (L398C)-VC-MMAD ADC | VC (valine-citrulline) | MMAD (monomethyl auristatin D) |
| ADC-W-198 | Anti-TPBG (clone H8)-AcPac-CalichDMH ADC | AcPac (3-acetylphenyl acidic acid) | CalichDMH (Calicheamicin (CM)) |
| ADC-W-008 | Anti-TPBG (clone A1)-AcBut-calicheamicin ADC | AcBut [-(4' acetyl phenoxy) butanoic acid] | calicheamicin |
| CAT# | Product Name | Linker | Payload |
| ADC-W-457 | Anti-MST1R (clone Zt/g4)-SMCC-DM1 ADC | SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate) | DM1 (N2’-Deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine) |
| ADC-W-504 | Anti-EGFR (cetuximab)-SMCC-Doxorubicin ADC | SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate) | Doxorubicin |
| ADC-W-2583 | Anti-EGFR (Zalutumumab)-SMCC-DM1 ADC | SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate) | DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine) |
| ADC-W-2598 | Anti-GPNMB (Glembatumumab)-SMCC-DM1 ADC | SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate) | DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine) |
| ADC-W-2571 | Anti-SLC34A2 (Lifastuzumab )-SMCC-DM1 ADC | SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate) | DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine) |
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