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Anti-TPBG (clone A1)-AcBut-calicheamicin ADC (CAT#: ADC-W-008)

This ADC product is comprised of an anti-TPBG monoclonal antibody (clone A1) conjugated via an AcBut linker to calicheamicin. The calicheamicin is targeted to TPBG-positive cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, calicheamicin binds to DNA, causes DNA damage, and subsequently, induces cell death.

  • Product Information
  • ADC Target
  • ADC Antibody
  • ADC Linker
  • ADC payload drug
  • Antibody clone #
  • A1
  • Name
  • TPBG
  • Alternative Names
  • M6P1; TPBGAG; WAIF1; TPBG oncofetal antigen; TPBG oncotrophoblast glycoprotein; wnt-activated inhibitory factor 1; TPBG oncofetal trophoblast glycoprotein;
  • Target Entrez Gene ID
  • 7162
  • Overview
  • This gene encodes a leucine-rich transmembrane glycoprotein that may be involved in cell adhesion. The encoded protein is an oncofetal antigen that is specific to trophoblast cells. In adults this protein is highly expressed in many tumor cells and is associated with poor clinical outcome in numerous cancers. Alternate splicing in the 5 UTR results in multiple transcript variants that encode the same protein.
  • Overview
  • Humanized Anti-TPBG IgG1 antibody, clone # A1
  • Clone #
  • A1
  • Species Reactivity
  • Human
  • Name
  •  AcBut [-(4' acetyl phenoxy) butanoic acid]
  • Description
  • Disulfide Linkers, are extensively exploited as a chemically labile linkage. Since the release of disulfide-linked drugs requires a cytoplasmic thiol cofactor, such as glutathione (GSH). Disulfides maintain stable at physiological pH and only when ADCs are internalized inside cells, the cytosol provides reducing environment including intracellular enzyme protein disulfide isomerase, or similar enzymes, drugs can be released.
  • Name
  • calicheamicin
  • Description
  • Calicheamicin,produced by prokaryotic microorganisms, are a group of DNA cleaving agents with similar structure that binds in the minor grove of DNA in a relatively sequence-specific manner.

For Research Use Only. NOT FOR CLINICAL USE.

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ADC-W-199 Anti-TPBG (clone H8)-Amide-CalichDMH ADC Amide (4-mercapto-4-methyl-pentanoic acid) CalichDMH (Calicheamicin (CM))
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CAT# Product Name Linker Payload
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ADC-W-332 Anti-CD22 (clone 10F4)-AcBut-Calicheamicin ADC  AcBut [-(4' acetyl phenoxy) butanoic acid] calicheamicin
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ADC-W-357 Anti-CD33 (clone HuM195)-AcBut-Calicheamicin ADC  AcBut [-(4' acetyl phenoxy) butanoic acid] calicheamicin
ADC-W-018 Anti-EFNA4 (clone huE22)-AcBut-CM ADC  AcBut [-(4' acetyl phenoxy) butanoic acid] CM (N-acetyl-y-calicheamicin dimethyl hydrazide)
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ADC-W-357 Anti-CD33 (clone HuM195)-AcBut-Calicheamicin ADC  AcBut [-(4' acetyl phenoxy) butanoic acid] calicheamicin
ADC-W-556 Anti-EphA4-calicheamicin ADC Calicheamicin
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ADC-W-338 Anti-CD22 (Inotuzumab)-hydrazone-Calicheamicin ADC hydrazone calicheamicin
WJY-0423-LS106 Protein A-Calicheamicin ADC Cleavable linkers Calicheamicin

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