- Home
- Products
- Customized ADCs
- F3
- Anti-F3 (clone b12)-VC-MMAE ADC
Anti-F3 (clone b12)-VC-MMAE ADC (CAT#: ADC-W-440)
This ADC product is comprised of an anti-F3 monoclonal antibody (clone b12) conjugated via a VC linker to MMAF. The MMAF is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, MMAF binds to tubulins, interrupts microtubule dynamics, and subsequently, induces cell death.
- Product Information
- ADC Target
- ADC Antibody
- ADC Linker
- ADC payload drug
- Antibody clone #
- b12
- Name
- F3
- Alternative Names
- F3; coagulation factor III (thromboplastin, tissue factor); TF; TFA; CD142; tissue factor;
- Target Entrez Gene ID
- 2152
- Target UniProt ID
- P13726
- Overview
- This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.
- Overview
- Human Anti-F3 lgG1 Antibody, clone # B12
- Clone #
- b12
- Species Reactivity
- Human
- Name
- VC (valine-citrulline)
- Description
- Peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.
- Name
- MMAE (Monomethyl auristatin E)
- Description
- Derived from Auristatin,are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.
For Research Use Only. NOT FOR CLINICAL USE.
Related Products
- Anti-ITGB2 (Erlizumab)-MC-MMAF ADC (CAT#: ADC-W-1510)
- Anti-C. diff Toxin A (Actoxumab)-MC-Vc-PAB-DMEA-(PEG2)-duocarmycin SA ADC (CAT#: ADC-W-2053)
- Anti-F3 (HuMab-TF-011)-Mc-MMAF ADC (CAT#: ADC-W-045)
- Anti-CSF2 (Lenzilumab)-MC-MMAF ADC (CAT#: ADC-W-2308)
- Anti-CTAA16.88 (Votumumab)-MC-Vc-PAB-SN38 ADC (CAT#: ADC-W-2046)
- Anti-IGF1R (Robatumumab)-MC-MMAF ADC (CAT#: ADC-W-1252)
- Anti-RTN4 (Atinumab)-SPDB-DM4 ADC (CAT#: ADC-W-1737)
- Anti-C. diff toxin B (Bezlotoxumab)-MC-Vc-PAB-SN38 ADC (CAT#: ADC-W-2064)
- Anti-MS4A1 (Obinutuzumab)-SPDB-DM4 ADC (CAT#: ADC-W-2469)
- Anti-IGF1 (Ganitumab)-SPDB-DM4 ADC (CAT#: ADC-W-1239)
Published Data
+ Submit Publications
Scientific Resources
Customer Reviews and FAQs
There are currently no Customer reviews or questions for ADC-W-440. Click the button above to contact us or submit your feedback about this product.
Quick Links
Other Products
Same Target
Same Linker
Same Payload
| CAT# | Product Name | Linker | Payload |
| ADC-W-049 | Anti-F3 (HuMab-TF-114)-Mc-MMAF ADC | Mc (maleimidocaproyl) | MMAF (Monomethyl auristatin F) |
| ADC-W-043 | Anti-F3 (HuMab-TF-098)-Mc-MMAF ADC | Mc (maleimidocaproyl) | MMAF (Monomethyl auristatin F) |
| ADC-W-047 | Anti-F3 (HuMab-TF-111)-Mc-MMAF ADC | Mc (maleimidocaproyl) | MMAF (Monomethyl auristatin F) |
| ADC-W-044 | Anti-F3 (HuMab-TF-011)-VC-MMAE ADC | VC (valine-citrulline) | MMAE (Monomethyl auristatin E) |
| ADC-W-439 | Anti-F3 (clone b12)-Mc-MMAF ADC | Mc (maleimidocaproyl) | MMAF (Monomethyl auristatin F) |
| CAT# | Product Name | Linker | Payload |
| ADC-AA-056 | Anti-MIgG (clone 187.1)-VC-MMAE ADC | VC (valine-citrulline) | MMAE (Monomethyl auristatin E) |
| ADC-W-514 | Anti-ERBB2 (Trastuzumab)-VC-DUBA ADC | VC (valine-citrulline) | seco-DUBA (DUocarmycin hydroxyBenzamide Azaindole) |
| ADC-W-477 | Anti-NECTIN4-VC-MMAE ADC | VC (valine-citrulline) | MMAE (Monomethyl auristatin E) |
| ADC-W-471 | Anti-CD70-VC-MED-2460-ADC | VC (valine-citrulline) | MED-2460 |
| ADC-W-486 | Anti-CD37-VC-MMAE ADC | VC (valine-citrulline) | MMAE (Monomethyl auristatin E) |
| CAT# | Product Name | Linker | Payload |
| ADC-AA-052 | Protein A-VC-MMAE ADC | VC (valine-citrulline) | MMAE (Monomethyl auristatin E) |
| ADC-W-465 | Anti-TNFRSF8 (Brentuximab)-VC-PAB-MMAE ADC | VC-PAB (valine-citrulline with PAB) | MMAE (Monomethyl auristatin E) |
| ADC-W-499 | Anti-SLC34A2 (Lifastuzumab)-VC-MMAE ADC | mc-VC-PABC | MMAE (Monomethyl auristatin E) |
| ADC-W-462 | Anti-GPNMB-VC-MMAE ADC | VC (valine-citrulline) | MMAE (Monomethyl auristatin E) |
| ADC-AA-056 | Anti-MIgG (clone 187.1)-VC-MMAE ADC | VC (valine-citrulline) | MMAE (Monomethyl auristatin E) |
Online Inquiry
Welcome! For price inquiries, please feel free to contact us through the form on the left side. We will get back to you as soon as possible.
