- Home
- Products
- Customized ADCs
- GPNMB
- Anti-GPNMB-VC-MMAE ADC
Anti-GPNMB-VC-MMAE ADC (CAT#: ADC-W-462)
This ADC product is comprised of an anti-GPNMB monoclonal antibody conjugated via a VC linker to MMAF. The MMAF is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, MMAF binds to tubulins, interrupts microtubule dynamics, and subsequently, induces cell death.
- Product Information
- ADC Target
- ADC Antibody
- ADC Linker
- ADC payload drug
- Similar to
- Glembatumumab vedotin ( CDX-011)
- Name
- GPNMB
- Alternative Names
- GPNMB; glycoprotein (transmembrane) nmb; NMB; HGFIN; transmembrane glycoprotein NMB; osteoactivin; glycoprotein NMB; glycoprotein nmb-like protein; transmembrane glycoprotein HGFIN;
- Target Entrez Gene ID
- 10457
- Target UniProt ID
- Q14956
- Overview
- The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene.
- Overview
- Human Anti-GPNMB Antibody
- Generic name
- Glembatumumab
- Species Reactivity
- Human
- Name
- VC (valine-citrulline)
- Description
- Peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.
- Name
- MMAE (Monomethyl auristatin E)
- Description
- Derived from Auristatin,are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.
For Research Use Only. NOT FOR CLINICAL USE.
Related Products
- Anti-CD70 (clone 2F2)-VC-MMAE ADC (CAT#: ADC-W-083)
- Anti-VEGFA (Vanucizumab)-MC-Vc-PAB-SN38 ADC (CAT#: ADC-W-2292)
- Anti-CD80 (Galiximab)-MC-Vc-PAB-MMAE ADC (CAT#: ADC-W-959)
- Anti-APP (Crenezumab)-MC-Vc-PAB-MMAE ADC (CAT#: ADC-W-689)
- Anti-ITGB3 (Tadocizumab)-MC-Vc-PAB-SN38 ADC (CAT#: ADC-W-2608)
- Anti-RhD (Morolimumab)-SMCC-DM1 ADC (CAT#: ADC-W-1724)
- Anti-MS4A1 (Ocaratuzumab)-MC-MMAF ADC (CAT#: ADC-W-1564)
- Anti-NOTCH2 (Tarextumab)-MC-MMAF ADC (CAT#: ADC-W-2218)
- Anti-ACVR2B (Bimagrumab)-MC-Vc-PAB-SN38 ADC (CAT#: ADC-W-654)
- Anti-CEACAM1 (clone T84.66) scFv-dextran T-40-MMC ADC (CAT#: ADC-W-381)
Published Data
+ Submit Publications
Scientific Resources
Customer Reviews and FAQs
There are currently no Customer reviews or questions for ADC-W-462. Click the button above to contact us or submit your feedback about this product.
Quick Links
Other Products
Same Target
Same Linker
Same Payload
| CAT# | Product Name | Linker | Payload |
| ADC-W-2603 | Anti-GPNMB (Glembatumumab)-MC-Vc-PAB-DMEA-(PEG2)-duocarmycin SA ADC | MC-Vc-PAB-DMEA-(PEG2) | duocarmycin SA |
| ADC-W-2598 | Anti-GPNMB (Glembatumumab)-SMCC-DM1 ADC | SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate) | DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine) |
| ADC-W-2602 | Anti-GPNMB (Glembatumumab)-MC-Vc-PAB-SN38 ADC | MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) | SN-38 (7-ethyl-10-hydroxycamptothecin) |
| ADC-W-2601 | Anti-GPNMB (Glembatumumab)-MC-Vc-PAB-MMAE ADC | MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) | MMAE |
| ADC-W-2600 | Anti-GPNMB (Glembatumumab)-MC-MMAF ADC | MC (maleimidocaproyl) | MMAF |
| CAT# | Product Name | Linker | Payload |
| ADC-W-477 | Anti-NECTIN4-VC-MMAE ADC | VC (valine-citrulline) | MMAE (Monomethyl auristatin E) |
| ADC-W-536 | Anti-EDNRB (endothelin B)-VC-MMAE ADC | VC (valine-citrulline) | MMAE (Monomethyl auristatin E) |
| ADC-W-494 | Anti-SLC39A6-VC-MMAE ADC | VC (valine-citrulline) | MMAE (Monomethyl auristatin E) |
| ADC-W-471 | Anti-CD70-VC-MED-2460-ADC | VC (valine-citrulline) | MED-2460 |
| ADC-W-565 | Anti-EDNRB-VC-MMAE ADC | VC (valine-citrulline) | MMAE (Monomethyl auristatin E) |
| CAT# | Product Name | Linker | Payload |
| ADC-AA-048 | Protein G-VC-MMAE ADC | VC (valine-citrulline) | MMAE (Monomethyl auristatin E) |
| ADC-AA-011 | anti-HIgG(Fc)Fab-C-MMAE ADC | Cleavable linkers | MMAE (Monomethyl auristatin E) |
| ADC-AA-056 | Anti-MIgG (clone 187.1)-VC-MMAE ADC | VC (valine-citrulline) | MMAE (Monomethyl auristatin E) |
| ADC-AA-021 | anti-MIgG(Fc)-C-MMAE ADC | Cleavable linkers | MMAE (Monomethyl auristatin E) |
| ADC-W-564 | Anti-MUC16-VC-MMAE ADC | VC (valine-citrulline) | MMAE (Monomethyl auristatin E) |
Online Inquiry
Welcome! For price inquiries, please feel free to contact us through the form on the left side. We will get back to you as soon as possible.
