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Anti-MUC1 (clone ch3A5)-VC-MMAF ADC (CAT#: ADC-W-241)

This ADC product is comprised of an anti-MUC1 monoclonal antibody (clone ch3A5) conjugated via a VC linker to MMAF. The MMAF is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, MMAF binds to tubulins, interrupts microtubule dynamics, and subsequently, induces cell death.

  • Product Information
  • ADC Target
  • ADC Antibody
  • ADC Linker
  • ADC payload drug
  • Antibody clone #
  • ch3A5
  • Name
  • MUC1
  • Alternative Names
  • MUC1; mucin 1, cell surface associated; EMA; MCD; PEM; PUM; KL-6; MAM6; MCKD; PEMT; CD227; H23AG; MCKD1; MUC-1; ADMCKD; ADMCKD1; CA 15-3; MUC-1/X; MUC1/ZD; MUC-1/SEC; mucin-1; episialin; DF3 antigen; H23 antigen; cancer antigen 15-3; krebs von den Lungen-
  • Target Entrez Gene ID
  • 4582
  • Overview
  • This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants.
  • Overview
  • Chimeric Anti-MUC1 lgG1 Antibody, clone # ch3A5
  • Clone #
  • ch3A5
  • Species Reactivity
  • Human
  • Name
  • VC (valine-citrulline)
  • Description
  • Peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.
  • Name
  • MMAF (Monomethyl auristatin F)
  • Description
  • Derived from Auristatin,are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

For Research Use Only. NOT FOR CLINICAL USE.

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Same Target Same Linker Same Payload
CAT# Product Name Linker Payload
ADC-W-2431 Anti-MUC1 (Pemtumomab)-MC-Vc-PAB-DMEA-(PEG2)-duocarmycin SA ADC MC-Vc-PAB-DMEA-(PEG2) duocarmycin SA
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ADC-W-2487 Anti-MUC1 (Sontuzumab)-SPDB-DM4 ADC SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate) DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
CAT# Product Name Linker Payload
ADC-W-564 Anti-MUC16-VC-MMAE ADC VC (valine-citrulline) MMAE (Monomethyl auristatin E)
ADC-W-514 Anti-ERBB2 (Trastuzumab)-VC-DUBA ADC VC (valine-citrulline) seco-DUBA (DUocarmycin hydroxyBenzamide Azaindole)
ADC-W-486 Anti-CD37-VC-MMAE ADC VC (valine-citrulline) MMAE (Monomethyl auristatin E)
ADC-W-475 Anti-CA9-VC-MMAE ADC VC (valine-citrulline) MMAE (Monomethyl auristatin E)
ADC-W-477 Anti-NECTIN4-VC-MMAE ADC VC (valine-citrulline) MMAE (Monomethyl auristatin E)
CAT# Product Name Linker Payload
ADC-AA-009 anti-HIgG(Fc)Fab-N-MMAF ADC Noncleavable linkers MMAF (Monomethyl auristatin F)
ADC-AA-028 anti-MIgG(Fc)Fab-C-MMAF ADC Cleavable linkers MMAF (Monomethyl auristatin F)
ADC-AA-027 anti-MIgG(Fc)Fab-N-MMAF ADC Noncleavable linkers MMAF (Monomethyl auristatin F)
ADC-AA-019 anti-MIgG(Fc)-N-MMAF ADC Noncleavable linkers MMAF (Monomethyl auristatin F)
ADC-AA-001 anti-HIgG(Fc)-N-MMAF ADC Noncleavable linkers MMAF (Monomethyl auristatin F)

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