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Anti-STEAP-1 (clone 120v.24)-Mc-VC-PABC-MMAE ADC (CAT#: ADC-W-143)

This ADC product is comprised of an anti-STEAP1 monoclonal antibody (clone 120v.24) conjugated via a Mc-VC-PABC linker to MMAE. The MMAE is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, MMAE binds to tubulins, interrupts microtubule dynamics, and subsequently, induces cell death.

  • Product Information
  • ADC Target
  • ADC Antibody
  • ADC Linker
  • ADC payload drug
  • Antibody clone #
  • 120v.24
  • Name
  • STEAP
  • Alternative Names
  • STEAP1; six transmembrane epithelial antigen of the prostate 1; STEAP; PRSS24; metalloreductase STEAP1; six-transmembrane epithelial antigen of prostate 1;
  • Target Entrez Gene ID
  • 26872
  • Overview
  • This gene is predominantly expressed in prostate tissue, and is found to be upregulated in multiple cancer cell lines. The gene product is predicted to be a six-transmembrane protein, and was shown to be a cell surface antigen significantly expressed at cell-cell junctions.
  • Overview
  • Anti-STEAP antibody, clone # 120v.24
  • Clone #
  • 120v.24
  • Species Reactivity
  • Human
  • Name
  • MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl)
  • Description
  • Peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.
  • Name
  • MMAE (Monomethyl auristatin E)
  • Description
  • Derived from Auristatin,are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

For Research Use Only. NOT FOR CLINICAL USE.

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CAT# Product Name Linker Payload
ADC-W-145 Anti-STEAP-1 (clone 120)-Mc-VC-PABC-MMAE ADC MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) MMAE (Monomethyl auristatin E)
ADC-W-144 Anti-STEAP-1 (clone 120v.24)-Mc-MMAF ADC Mc (maleimidocaproyl) MMAF (Monomethyl auristatin F)
ADC-W-147 Anti-STEAP-1 (clone 120)-VC-MMAE ADC VC (valine-citrulline) MMAE (Monomethyl auristatin E)
ADC-W-146 Anti-STEAP-1 (clone 120)-Mc-MMAF ADC Mc (maleimidocaproyl) MMAF (Monomethyl auristatin F)
CAT# Product Name Linker Payload
ADC-W-506 Anti-VTCN1 (clone h1D11)-MC-vc-PABC-MMAE ADC MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) MMAE (Monomethyl auristatin E)
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ADC-W-587 Anti-CD70 (clone h1F6 )-Mc-VC-PABC-MMAE ADC MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) MMAE (Monomethyl auristatin E)
ADC-W-616 Anti-CD19 (B496)-Mc-MMAF ADC MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) MMAF (Monomethyl auristatin F)
ADC-W-604 Anti-FUT3 (clone BR96)-Mc-VC-PABC-MMAF ADC MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) MMAF (Monomethyl auristatin F)
CAT# Product Name Linker Payload
ADC-AA-003 anti-HIgG(Fc)-C-MMAE ADC Cleavable linkers MMAE (Monomethyl auristatin E)
ADC-AA-052 Protein A-VC-MMAE ADC VC (valine-citrulline) MMAE (Monomethyl auristatin E)
ADC-AA-029 anti-MIgG(Fc)Fab-C-MMAE ADC Cleavable linkers MMAE (Monomethyl auristatin E)
ADC-AA-021 anti-MIgG(Fc)-C-MMAE ADC Cleavable linkers MMAE (Monomethyl auristatin E)
ADC-AA-056 Anti-MIgG (clone 187.1)-VC-MMAE ADC VC (valine-citrulline) MMAE (Monomethyl auristatin E)

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