ADC Linker Products

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Product Overview

Creative Biolabs offers a variety of chemically versatile linker molecules to facilitate antibody-drug conjugate (ADC) development projects. All chemical linkers are of >95% purity and they are the basic building blocks for a successful ADC. Linkers facilitate the conjugation of ADC toxins to antibodies and in the meantime, they also dictate the release mechanism of an ADC. Proper linker selection will not only ease the process of obtaining the conjugate but also help enhance the chemical and serum stability of the ADC. Creative Biolabs carries a series of cleavable linkers (pH-sensitive linkers, disulfide linker, peptide linkers, β-glucuronide linkers), non-cleavable linkers, and intermediate linker modules. In the meantime, we also offer the services in the DrugLnk synthesis platform to prepare customized linkers with unique structures.

ADC Linker Services

Creative Biolabs offers a comprehensive "DrugLnk" linker module designed to cater to the diverse needs of antibody-drug conjugate (ADC) development. This module focuses on the design and preparation of various types of linkers, tailored to their specific drug release mechanisms. Clients can choose from a range of linker types:

Leveraging an advanced synthetic chemistry platform along with an extensive inventory of toxins, linkers, and drug-linker sets, "DrugLnk" at Creative Biolabs enables our skilled chemists to provide specialized services.

(1) Design linkers with optimal size
(2) Select linkers with suitable release mechanism
(3) Engineer linkers with compatible conjugation chemistry
(4) Synthesize customized linkers
(5) Modify payload drug
(6) Design synthesis routes
(7) Synthesize customized drug-linker complexes

Please feel free to contact us for more information about our ADC linker services.

Scientific Resources

CAMouse™-Fully Human Antibody Generation Platform

Global Antibody-drug Conjugate (ADC) Clinical Trial ReviewGlobal Antibody-drug Conjugate (ADC) Clinical Trial Review 2018.3

Creative Biolabs ADC Product Brochure

Protocol

Quick Links

ADC Toxins

Drug-linker Complexes

Customized ADCs

Anti-Ab ADCs

Product List

Functional Group 1:

Reactive Group 1:

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Functional Group 2:

Reactive Group 2:

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PEG/Non-PEG:

Cleavable/Non-Cleavable:

Catalog	Product name	CAS NO	Structure	Molecular Weight	Purity	Data sheet	Inquiry
ADC-L-1014	Mal-PEG1-Val-Cit-OH			469.5	95%		Inquiry
ADC-L-1015	Mal-PEG1-Val-Cit-PABC-OH	2055041-37-5		574.64	95%		Inquiry
ADC-L-1016	Mal-PEG1-Val-Cit-PABC-PNP	2249935-92-8		739.74	95%		Inquiry
ADC-L-1017	MC-Val-Ala-PAB	1870916-87-2		486.57	95%		Inquiry
ADC-L-1018	MC-Val-Ala-PAB-PNP	1639939-40-4		651.67	95%		Inquiry
ADC-L-1019	TCO-PEG1-Val-Cit-OH			541.65	95%		Inquiry
ADC-L-1020	TCO-PEG1-Val-Cit-PABC-OH			646.79	95%		Inquiry
ADC-L-1021	TCO-PEG1-Val-Cit-PABC-PNP			811.89	95%		Inquiry
ADC-L-1022	Fmoc-Ala-Ala-Asn(Trt)-OH	1951424-92-2		738.83	95%		Inquiry
ADC-L-1023	(2S,3S,4S,5R,6S)-methyl-6-(2-(3-((Fmoc-amino)propanamido)-4-PNB-3,4,5-triacetoxy-tetrahydro-2H-pyran-2-carboxylate	894095-98-8		913.84	95%		Inquiry
ADC-L-1024	4-Formyl-2-nitrophenyl-β-D-Glucopyranosiduronic Acid Methyl Ester 2,3,4-Triacetate	148579-93-5		483.38	95%		Inquiry
ADC-L-1025	β-D-Glucopyranosiduronic acid, 2-amino-4-(hydroxymethyl)phenyl, methyl ester, 2,3,4-triacetate	229977-57-5		455.42	95%		Inquiry
ADC-L-1026	β-D-tetraacetylgalactopyranoside-PEG2-N3	153252-36-9		461.42	95%		Inquiry
ADC-L-1027	β-D-triacetylglucopyranosiduronyl methyl ester-phenol-β-Alanine	894096-02-7		748.74	95%		Inquiry
ADC-L-1028	Aldehyde-benzyl-PEG5-alkyne	1378928-83-6		336.38	95%		Inquiry
ADC-L-1029	Acid-propionylamino-Val-Cit-OH	2098907-84-5		374.39	95%		Inquiry
ADC-L-1030	N3-PEG1-Val-Cit-OH			415.45	95%		Inquiry
ADC-L-1031	N3-PEG1-Val-Cit-PABC-OH	2055041-40-0		520.59	95%		Inquiry
ADC-L-1032	N3-PEG1-Val-Cit-PABC-PNP			685.7	95%		Inquiry
ADC-L-1033	BCN-PEG1-Val-Cit-OH			565.67	95%		Inquiry