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ADC Linker Products

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Product Overview

Creative Biolabs offers a variety of chemically versatile linker molecules to facilitate antibody-drug conjugate (ADC) development projects. All chemical linkers are of >95% purity and they are the basic building blocks for a successful ADC. Linkers facilitate the conjugation of ADC toxins to antibodies and in the meantime, they also dictate the release mechanism of an ADC. Proper linker selection will not only ease the process of obtaining the conjugate but also help enhance the chemical and serum stability of the ADC. Creative Biolabs carries a series of cleavable linkers (pH-sensitive linkers, disulfide linker, peptide linkers, β-glucuronide linkers), non-cleavable linkers, and intermediate linker modules. In the meantime, we also offer the services in the DrugLnk synthesis platform to prepare customized linkers with unique structures.

ADC Linker Services

Creative Biolabs offers a comprehensive "DrugLnk" linker module designed to cater to the diverse needs of antibody-drug conjugate (ADC) development. This module focuses on the design and preparation of various types of linkers, tailored to their specific drug release mechanisms. Clients can choose from a range of linker types:

Leveraging an advanced synthetic chemistry platform along with an extensive inventory of toxins, linkers, and drug-linker sets, "DrugLnk" at Creative Biolabs enables our skilled chemists to provide specialized services.

(1) Design linkers with optimal size
(2) Select linkers with suitable release mechanism
(3) Engineer linkers with compatible conjugation chemistry
(4) Synthesize customized linkers
(5) Modify payload drug
(6) Design synthesis routes
(7) Synthesize customized drug-linker complexes

Please feel free to contact us for more information about our ADC linker services.

Scientific Resources

CAMouse™-Fully Human Antibody Generation Platform
Global Antibody-drug Conjugate (ADC) Clinical Trial ReviewGlobal Antibody-drug Conjugate (ADC) Clinical Trial Review 2018.3
Development of Monoclonal Antibodies
Creative Biolabs ADC Product Brochure
CAMouse™-Fully Human Antibody Generation Platform
Protocol

Quick Links

ADC Toxins
Drug-linker Complexes
Customized ADCs
Anti-Ab ADCs

Product List

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Catalog Product name CAS NO Structure Molecular Weight Purity Data sheet Inquiry
ADC-L-Y0066 Bis-propargyl-PEG2 40842-04-4 Bis-propargyl-PEG2 138.2 95% Inquiry
ADC-L-Y0068 Bis-propargyl-PEG4 126422-58-0 Bis-propargyl-PEG4 226.3 95% Inquiry
ADC-L-Y0069 Bis-propargyl-PEG5 159428-42-9 Bis-propargyl-PEG5 270.3 95% Inquiry
ADC-L-Y0070 Bis-propargyl-PEG6 185378-83-0 Bis-propargyl-PEG6 314.4 95% Inquiry
ADC-L-Y0071 Bis-propargyl-PEG7 400775-35-1 Bis-propargyl-PEG7 358.4 95% Inquiry
ADC-L-Y0072 Bis-propargyl-PEG8 1351373-46-0 Bis-propargyl-PEG8 402.5 95% Inquiry
ADC-L-Y0073 Bis-propargyl-PEG9 1092554-87-4 Bis-propargyl-PEG9 446.5 95% Inquiry
ADC-L-Y0074 Bis-propargyl-PEG10 1351373-47-1 Bis-propargyl-PEG10 490.6 95% Inquiry
ADC-L-Y0075 Bis-propargyl-PEG12 1351373-49-3 Bis-propargyl-PEG12 578.7 95% Inquiry
ADC-L-Y0076 Bis-propargyl-PEG13 1351373-50-6 Bis-propargyl-PEG13 622.8 95% Inquiry
ADC-L-Y0077 Bis-propargyl-PEG14 124238-56-8 Bis-propargyl-PEG14 666.8 95% Inquiry
ADC-L-Y0078 Bis-propargyl-PEG18 124238-56-8 Bis-propargyl-PEG18 843 95% Inquiry
ADC-L-Y0081 Propargyl-PEG4-methylamine 1807530-11-5 Propargyl-PEG4-methylamine 245.3 95% Inquiry
ADC-L-Y0082 Propargyl-PEG3-Ms 943726-01-0 Propargyl-PEG3-Ms 222.3 95% Inquiry
ADC-L-Y0083 Propargyl-PEG6-Ms 1036204-62-2 Propargyl-PEG6-Ms 354.4 95% Inquiry
ADC-L-Y0088 t-Boc-aminooxy-PEG2-propargyl 1895922-74-3 t-Boc-aminooxy-PEG2-propargyl 259.3 95% Inquiry
ADC-L-Y0089 t-Boc-aminooxy-PEG3-propargyl 1951439-46-5 t-Boc-aminooxy-PEG3-propargyl 303.4 95% Inquiry
ADC-L-Y0090 t-Boc-aminooxy-PEG4-propargyl 1895922-77-6 t-Boc-aminooxy-PEG4-propargyl 347.4 95% Inquiry
ADC-L-Y0091 t-Boc-aminooxy-PEG5-propargyl 2086688-98-2 t-Boc-aminooxy-PEG5-propargyl 391.5 95% Inquiry
ADC-L-Y0092 t-Boc-aminooxy-PEG6-propargyl 2093152-83-9 t-Boc-aminooxy-PEG6-propargyl 435.5 95% Inquiry
If you can’t find your product on this list? Please directly send email to info@creative-biolabs.com

For Research Use Only. NOT FOR CLINICAL USE.

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