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SLC39A6
Anti-SLC39A6 (clone hLIV22)-VC-MMAE ADC

Anti-SLC39A6 (clone hLIV22)-VC-MMAE ADC (CAT#: ADC-W-425)

This ADC product is comprised of an anti-SLC39A6 monoclonal antibody (clone hLIV22) conjugated via a VC linker to MMAE. The MMAE is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, MMAE binds to tubulins, interrupts microtubule dynamics, and subsequently, induces cell death.

Product Information
ADC Target
ADC Antibody
ADC Linker
ADC payload drug

Antibody clone #
hLIV22

Name
SLC39A6

Alternative Names
SLC39A6; solute carrier family 39 (zinc transporter), member 6; LIV-1; zinc transporter ZIP6; ZIP-6; zrt-and Irt-like protein 6; estrogen-regulated protein LIV-1; LIV-1 protein, estrogen regulated; solute carrier family 39 member 6; solute carrier family

Target Entrez Gene ID
25800

Target UniProt ID
Q13433

Overview
Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A6 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003 [PubMed 12659941]).

Overview
Anti-SLC39A6 Antibody, clone # HLIV22

Clone #
hLIV22

Species Reactivity
Human

Name
VC (valine-citrulline)

Description
Peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.

Name
MMAE (Monomethyl auristatin E)

Description
Derived from Auristatin,are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

For Research Use Only. NOT FOR CLINICAL USE.

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CAMouse™-Fully Human Antibody Generation Platform

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Other Products

Same Target Same Linker Same Payload

CAT#	Product Name	Linker	Payload
ADC-W-494	Anti-SLC39A6-VC-MMAE ADC	VC (valine-citrulline)	MMAE (Monomethyl auristatin E)

CAT#	Product Name	Linker	Payload
ADC-AA-056	Anti-MIgG (clone 187.1)-VC-MMAE ADC	VC (valine-citrulline)	MMAE (Monomethyl auristatin E)
ADC-W-476	Anti-SLC44A4 (AGS-5)-VC-MMAE ADC	VC (valine-citrulline)	MMAE (Monomethyl auristatin E)
ADC-AA-048	Protein G-VC-MMAE ADC	VC (valine-citrulline)	MMAE (Monomethyl auristatin E)
ADC-W-565	Anti-EDNRB-VC-MMAE ADC	VC (valine-citrulline)	MMAE (Monomethyl auristatin E)
ADC-W-494	Anti-SLC39A6-VC-MMAE ADC	VC (valine-citrulline)	MMAE (Monomethyl auristatin E)

CAT#	Product Name	Linker	Payload
ADC-AA-029	anti-MIgG(Fc)Fab-C-MMAE ADC	Cleavable linkers	MMAE (Monomethyl auristatin E)
ADC-AA-021	anti-MIgG(Fc)-C-MMAE ADC	Cleavable linkers	MMAE (Monomethyl auristatin E)
ADC-AA-048	Protein G-VC-MMAE ADC	VC (valine-citrulline)	MMAE (Monomethyl auristatin E)
ADC-W-536	Anti-EDNRB (endothelin B)-VC-MMAE ADC	VC (valine-citrulline)	MMAE (Monomethyl auristatin E)
ADC-W-529	Anti-F3 (TF-011)-VC-MMAE ADC	VC (valine-citrulline)	MMAE (Monomethyl auristatin E)

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