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Anti-EDNRB (endothelin B)-VC-MMAE ADC

Anti-EDNRB (endothelin B)-VC-MMAE ADC (CAT#: ADC-W-536)

This ADC product is comprised of an anti-EDNRB monoclonal antibody conjugated via a VC linker to MMAE. The MMAE is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, MMAE binds to tubulins, interrupts microtubule dynamics, and subsequently, induces cell death.

Product Information
ADC Target
ADC Antibody
ADC Linker
ADC payload drug

Similar to
DEDN-6526A

Name
EDNRB

Alternative Names
EDNRB; endothelin receptor type B; ETB; ET-B; ETBR; ETRB; HSCR; WS4A; ABCDS; ET-BR; HSCR2; endothelin B receptor; endothelin receptor non-selective type;

Target Entrez Gene ID
1910

Target UniProt ID
P24530

Overview
The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Overview
Humanized Anti-EDNRB Antibody

Species Reactivity
Human

Name
VC (valine-citrulline)

Description
Peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.

Name
MMAE (Monomethyl auristatin E)

Description
Derived from Auristatin,are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

For Research Use Only. NOT FOR CLINICAL USE.

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CAMouse™-Fully Human Antibody Generation Platform

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Other Products

Same Target Same Linker Same Payload

CAT#	Product Name	Linker	Payload
ADC-W-601	Anti-EDNBR (clone 5E9)-VC-MMAE ADC	VC (valine-citrulline)	MMAE (Monomethyl auristatin E)
ADC-W-565	Anti-EDNRB-VC-MMAE ADC	VC (valine-citrulline)	MMAE (Monomethyl auristatin E)

CAT#	Product Name	Linker	Payload
ADC-W-398	Anti-EphA2 (clone 1C1)-VC-MMAE ADC	VC (valine-citrulline)	MMAE (Monomethyl auristatin E)
ADC-AA-048	Protein G-VC-MMAE ADC	VC (valine-citrulline)	MMAE (Monomethyl auristatin E)
ADC-W-565	Anti-EDNRB-VC-MMAE ADC	VC (valine-citrulline)	MMAE (Monomethyl auristatin E)
ADC-W-471	Anti-CD70-VC-MED-2460-ADC	VC (valine-citrulline)	MED-2460
ADC-W-476	Anti-SLC44A4 (AGS-5)-VC-MMAE ADC	VC (valine-citrulline)	MMAE (Monomethyl auristatin E)

CAT#	Product Name	Linker	Payload
ADC-W-465	Anti-TNFRSF8 (Brentuximab)-VC-PAB-MMAE ADC	VC-PAB (valine-citrulline with PAB)	MMAE (Monomethyl auristatin E)
ADC-W-529	Anti-F3 (TF-011)-VC-MMAE ADC	VC (valine-citrulline)	MMAE (Monomethyl auristatin E)
ADC-AA-052	Protein A-VC-MMAE ADC	VC (valine-citrulline)	MMAE (Monomethyl auristatin E)
ADC-AA-056	Anti-MIgG (clone 187.1)-VC-MMAE ADC	VC (valine-citrulline)	MMAE (Monomethyl auristatin E)
ADC-AA-021	anti-MIgG(Fc)-C-MMAE ADC	Cleavable linkers	MMAE (Monomethyl auristatin E)

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