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anti-MIgG(Fc)Fab-C-MMAE ADC (CAT#: ADC-AA-029)

This ADC product is comprised of a Fab fragment of an anti-mouse IgG Fc specific polyclonal antibody conjugated via a cleavable linker to MMAE. The antibody portion is a Fab fragment of a secondary antibody and the drug portion, MMAE, is a cytotoxic small molecule which binds to tubulins, interrupts microtubule dynamics, and induces cell death. This product displays no obvious toxicity without a primary antibody and can be a quite efficient and economical alternative to pre-screening mouse monoclonal antibodies as ADC candidates.

  • ADC Target
  • ADC Antibody
  • ADC Linker
  • ADC payload drug
  • Name
  • IgG Fc
  • Overview
  • The fragment crystallizable region (Fc region) is composed of the constant region of the two heavy chains that form the IgG molecule. The Fc region of IgG bears a highly conserved N-glycosylation site. Glycosylation of the Fc fragment is essential for Fc receptor-mediated activity. Fc binds to various cell receptors and complement proteins thus mediating different physiological effects of antibodies, such as opsonization, antibody dependent cellular cytotoxicity (ADCC), degranulation of mast cells, basophils, eosinophils and other processes.
  • Overview
  • Fab fragment of anti-mouse IgG Fc specific polyclonal antibody
  • Species Reactivity
  • Mouse
  • Name
  • Cleavable linkers
  • Description
  • Cleavable linkers rely on the physiological stimuli, which mainly include chemically cleavable linkers and enzymatically cleavable linkers. Chemically cleavable linkers including acid-labile linkers and disulfide linkers. For acid-labile linkers, intracellular release of payloads relies on the different pH between endosomes/lysosomes and blood. The release of disulfide-linked drugs is controlled by the factors in intracellular environment. Enzymatically cleavable linkers, peptide linkers and β-glucuronide linkers, are sensitive to enzymes located in cytoplasm.
  • Name
  • MMAE (Monomethyl auristatin E)
  • Description
  • Derived from Auristatin,are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

For Research Use Only. NOT FOR CLINICAL USE.

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Scientific Resources

CAMouse™-Fully Human Antibody Generation Platform
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Development of Monoclonal Antibodies
Literature
CAMouse™-Fully Human Antibody Generation Platform
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Customer Reviews FAQ
def-person
Excellent
Efficient Screening Tool
We used the anti-MIgG(Fc)Fab-C-MMAE ADC from Creative Biolabs for pre-screening our mouse monoclonal antibodies. Its selective cytotoxicity significantly streamlined our screening process, reducing both time and resource expenditure.
def-person
Excellent
Targeted Cytotoxicity
This ADC product delivered impressive results with minimal off-target effects. The MMAE component provided potent cytotoxic activity, proving crucial in our antibody candidate validation.
def-person
Excellent
Cost-Effective
The anti-MIgG(Fc)Fab-C-MMAE ADC from Creative Biolabs has been a game-changer for us. It's an economical alternative for ADC screening, saving us from costly full antibody conjugations in early experiments.
def-person
Excellent
Specificity and Efficacy
Impressed by the high specificity and efficacy of the Fab fragment in targeting mouse IgG Fc. The MMAE linker activation in the presence of a primary antibody worked flawlessly, confirming its utility in our labs.
def-person
Excellent
Research Enhancement
The anti-MIgG(Fc)Fab-C-MMAE ADC has enhanced the efficiency and accuracy of our research projects. It effectively induces cell death only in the presence of target antibodies, ensuring reliable results.

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Other Products

Same Target Same Linker Same Payload
CAT# Product Name Linker Payload
ADC-AA-048 Protein G-VC-MMAE ADC VC (valine-citrulline) MMAE (Monomethyl auristatin E)
ADC-AA-026 anti-MIgG(Fc)-N-DM1 ADC Noncleavable linkers DM1 (N2’-Deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine)
ADC-AA-021 anti-MIgG(Fc)-C-MMAE ADC Cleavable linkers MMAE (Monomethyl auristatin E)
ADC-AA-049 Protein G-MMAF ADC MMAF (Monomethyl auristatin F)
ADC-AA-031 anti-MIgG(Fc)Fab-N-DM1 ADC Noncleavable linkers DM1 (N2’-Deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine)
CAT# Product Name Linker Payload
ADC-AA-002 anti-HIgG(Fc)-C-MMAF ADC Cleavable linkers MMAF (Monomethyl auristatin F)
ADC-AA-028 anti-MIgG(Fc)Fab-C-MMAF ADC Cleavable linkers MMAF (Monomethyl auristatin F)
WJY-0423-LS107 Protein A-PBD ADC Cleavable linkers PBD (pyrrolobenzodiazepine)
ADC-AA-066 Anti-Rat IgG(H+L)-C-PBD ADC Cleavable linkers PBD (pyrrolobenzodiazepine)
ADC-AA-020 anti-MIgG(Fc)-C-MMAF ADC Cleavable linkers MMAF (Monomethyl auristatin F)
CAT# Product Name Linker Payload
ADC-W-499 Anti-SLC34A2 (Lifastuzumab)-VC-MMAE ADC mc-VC-PABC MMAE (Monomethyl auristatin E)
ADC-W-565 Anti-EDNRB-VC-MMAE ADC VC (valine-citrulline) MMAE (Monomethyl auristatin E)
ADC-AA-011 anti-HIgG(Fc)Fab-C-MMAE ADC Cleavable linkers MMAE (Monomethyl auristatin E)
ADC-W-536 Anti-EDNRB (endothelin B)-VC-MMAE ADC VC (valine-citrulline) MMAE (Monomethyl auristatin E)
ADC-W-564 Anti-MUC16-VC-MMAE ADC VC (valine-citrulline) MMAE (Monomethyl auristatin E)

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