VC-SECO DUBA (CAT#: ADC-S-029)

Linker-Toxin SET, this set is made by DUBA (DNA alkylating agent) conjugated to the lysosomally cleavable dipeptide, valine-citrulline (vc) linker. The DNA modifying agents such as duocarmycin are being used in the development of antibody-drug conjugate.

Product Information

CAS NO
1345681-58-4

Description
Linker-Toxin SET, this set is made by DUBA (DNA alkylating agent) conjugated to the lysosomally cleavable dipeptide, valine-citrulline (vc) linker. The DNA modifying agents such as duocarmycin are being used in the development of antibody-drug conjugate.

Molecular Weight
1331.81

Purity
95%

For Research Use Only. NOT FOR CLINICAL USE.

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Customer Reviews FAQ

Excellent

VC-SECO DUBA has been instrumental in our ADC research. The DUBA conjugation with the vc linker provided precise DNA alkylation, enhancing our results significantly. Creative Biolabs' product quality is outstanding, and we highly recommend it for advanced ADC development.

Excellent

The VC-SECO DUBA from Creative Biolabs has proven to be a game-changer in our experiments. The efficiency of the vc linker in combination with DUBA has produced consistent and reliable results, making it a valuable asset for our antibody-drug conjugate studies.

Excellent

Creative Biolabs' VC-SECO DUBA set has been pivotal in our ADC projects. The duocarmycin-based linker-toxin combination provided robust DNA modification, leading to successful outcomes in our studies. It's a reliable and potent tool for any ADC research.

Excellent

Our research benefited greatly from using VC-SECO DUBA. The combination of the DUBA agent with the vc linker allowed for efficient and targeted DNA modification, enhancing our ADC outcomes. Creative Biolabs provided a product that met all our needs.

Excellent

VC-SECO DUBA has been a key component in our ADC development efforts. The DUBA's conjugation with the vc linker was both effective and consistent, resulting in high-quality research data. Creative Biolabs' dedication to quality is evident in this product.

Q: 1: What is VC-SECO DUBA, and how is it used in ADCs?
A: VC-SECO DUBA is a linker-toxin set where the DNA alkylating agent DUBA is conjugated to a lysosomally cleavable dipeptide, valine-citrulline (vc) linker. This set is utilized in the development of antibody-drug conjugates (ADCs) to target and destroy cancer cells through DNA modification.
Q: 2: How does the valine-citrulline (vc) linker function in VC-SECO DUBA?
A: The valine-citrulline (vc) linker in VC-SECO DUBA is designed to be cleaved in the lysosome, a cellular organelle that degrades waste materials. Upon cleavage, the DNA alkylating agent DUBA is released inside the target cell, enabling it to modify the DNA and induce cell death.
Q: 3: What role does DUBA play in the VC-SECO DUBA linker-toxin set?
A: DUBA, a DNA alkylating agent, is the cytotoxic component of the VC-SECO DUBA set. Once released within the target cell, DUBA binds to DNA, causing modifications that disrupt essential cellular processes and lead to cell death, particularly in cancer cells.
Q: 4: How does the lysosomal environment affect the function of VC-SECO DUBA?
A: The lysosomal environment is crucial for the function of VC-SECO DUBA. The acidic conditions and specific enzymes within the lysosome cleave the valine-citrulline (vc) linker, triggering the release of the DNA alkylating agent DUBA and allowing it to exert its cytotoxic effects.
Q: 5: What potential challenges might arise when using VC-SECO DUBA in ADCs?
A: Potential challenges with using VC-SECO DUBA in ADCs include ensuring the stability of the linker-toxin set in circulation, achieving effective targeting of the ADC to the cancer cells, and managing any potential resistance mechanisms that may develop in the cancer cells.

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