shRNA Adenovirus Serotype 5 (ΔE1/E3), p7SK-(CASC4-shRNA-Seq2)(CAT#: AdV-SI1119WQ)
This product is a CASC4-shRNA encoding AdV, which is based on AdV-5 serotype with EIB-55K gene deleted. The increased expression level of CASC4 gene is associated with HER-2/neu proto-oncogene overexpression. Amplification and resulting overexpression of this proto-oncogene are found in approximately 30% of human breast and 20% of human ovarian cancers. The expression of CASC4-shRNA leads to target gene silencing and this product can be used in gene therapy research and development.
Specifications | |
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Family | Adenoviridae |
Species | Adenovirus |
Serotype | HAdV-5 |
Backbone | AdV-5 (ΔE1/E3) |
Tropism | Both nondividing and dividing cells |
Insert | CASC4-shRNA-Seq2 |
Related Target/Protein | CASC4 |
Region | CDS |
TargetSeq | GAATGAAGAACCCTCAAGCAA |
NCBI RefSeq | NM_138423 |
Alternative Names | H63 |
Titer | >1*10^10 GC/mL |
Related Diseases | Ovarian cancers, Breast cancer |