shRNA Adenovirus Serotype 5 (ΔE1/E3), p7SK-(Med25-shRNA-Seq1)(CAT#: AdV-SI3921WQ)
This product is a Med25-shRNA encoding AdV, which is based on AdV-5 serotype with E1/E3 gene deleted. The protein encoded by Med25 gene plays a role in chromatin modification and in preinitiation complex assembly. Mutations in this gene are associated with Charcot-Marie-Tooth disease type 2B2. The expression of Med25-shRNA leads to target gene silencing and this product can be used in gene therapy research and development.
Specifications | |
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Family | Adenoviridae |
Species | Adenovirus |
Serotype | AdV-5 |
Backbone | AdV-5 (ΔE1/E3) |
Tropism | Both nondividing and dividing cells |
Modification | ΔE1/E3 |
Insert | Med25-shRNA-Seq1 |
Related Target/Protein | Med25 |
Region | CDS |
TargetSeq | GCAGCTGTTCGATGACTTTAA |
NCBI RefSeq | NM_029365 |
Alternative Names | P78; ACID1; ARC92; BVSYS; PTOV2; CMT2B2; TCBAP0758 |
Titer | >1*10^10 GC/mL |
Related Diseases | Charcot-Marie-Tooth disease type 2B2 |