Creative Biolabs combines a diverse range of platforms with a team of tenured scientists who are experts in engineering HupT3 for pancreatic cancer cell self-destruction purposes.

Immunotherapy for Pancreatic Cancer

Pancreatic cancer is a highly lethal cancer. It has the lowest 5-year survival rate for several reasons, such as its tendency for late diagnosis, a lack of serologic markers for screening, aggressive local invasion, its early metastatic dissemination, and its resistance to chemotherapy/radiotherapy. Pancreatic cancer evades immunologic elimination by a variety of mechanisms. Immunotherapy is a class of treatments that take advantage of a person's own immune system to help kill cancer cells. Immunotherapy has the potential to mobilize the immune system to eliminate cancer cells. There are currently two approved immunotherapy options for a small subset of patients with pancreatic cancer, and many more are being investigated. Immunotherapeutic approaches for pancreatic cancer treatment deserve further exploration.

Fig.1 HupT3 cells were transfected with FLAG-tagged Bora, and irradiated by 10 Gy. (Cairns, et al., 2015)

Pancreatic Cancer Cell Line HupT3

In order to develop novel treatment regimens, especially the lack of chemotherapeutical options requires a better understanding of the molecular mechanisms leading to pancreatic carcinoma growth and progression. HupT3 is a human pancreatic adenocarcinoma cell line derived from an ascites sample taken from a 66-year-old Japanese male with a poorly differentiated pancreatic adenocarcinoma. HupT3 is a useful well-established pancreatic cancer cell line to identify signaling pathways that are critical for this tumor entity.

Pancreatic Cancer Cell HupT3 Engineering Service at Creative Biolabs

Evidence has shown that tumor lymphangiogenesis can enhance cancer immunotherapy and boost T cell immunity. Our scientists have been engaged in the study of tumor lymphangiogenesis for many years. We are exploring the lymphangiogenic potentiation of immunotherapy to Turning Cancer Cells Against Themselves.

HupT3 cell line is a useful model in the research of new therapy for pancreatic cancer. We have developed several different Genetic Methods, including Retrovirus, Lentivirus, Adenovirus, Adeno-associated Virus, and CRISPR-based Methods, to engineer HupT3 for cancer cell self-destruction purposes.

Our strategies for engineering cancer cells for self-destruction, include but are not limited to:

• Engineering Cancer Cells with Cytokine Overexpression for Stronger T Cell Activation
• Engineering Cancer Cells with Target-specific Aptamer for Cancer Immunotherapy
• Engineering Cancer Cells with Aptamer-siRNA for Enhanced Antitumor T Cell Immunity
• Engineering Cancer Cells with Synthetic Immunomodulatory Gene Circuits for Cancer Immunotherapy
• Engineering Cancer Cells with Targeted siRNA For Cancer Immunotherapy

We offer turn-key or ala carte services customized to our client's needs. For more detailed information, please feel free to contact us or directly send us an inquiry.

Reference

1. Cairns, J.; et al. Bora downregulation results in radioresistance by promoting repair of double strand breaks. Plos one. 2015, 10(3): e0119208.

For Research Use Only | Not For Clinical Use