Gut Microbiota Genomic Analysis Services

Gut microbiota composition analysis in humans and animals is important because of its emerging roles and applications in a broad range of diseases. Next-generation sequencing (NGS) is emerging as a powerful technology to gut microbiota investigation, allowing characterization of microbial communities at unprecedented resolution, without prior culturing. Based on our cutting-edge Gut Microbiota-based Diagnostics Platform, Creative Biolabs offers accurate and effective solutions for researchers who are committed to exploring the complexity of gut microbiota in humans.

Gut Microbiota and Human Health

Gut microbiota plays an essential role in human health. Increasing evidence suggests there is a relation between changes in the composition and activity of gut microbiota and the pathophysiology of several diseases. Dysbiosis in the gut microbiota may alter intestinal barrier functions, host metabolic and signaling pathways, which are directly or indirectly linked to various diseases and metabolic disorders such as obesity, diabetes, cardiovascular disease, inflammatory bowel disease, autoimmune diseases, neuropsychiatric disorders and cancers. However, the complexity of human gut microbiome is beyond our imagination. Until now, we can only see the tip of the iceberg yet. Further genomic studies are required to understand the impact of gut microbiome on human health. NGS is the current method of choice to analyze the composition of gut microbial community.

Gut Microbiota Genomic Analysis Services

Gut Microbiota Genomic Analysis Services at Creative Biolabs

At Creative Biolabs, the taxonomic profile of a gut microbial community can be obtained by 16S ribosomal RNA sequencing, shotgun metagenomic sequencing, single-cell genome sequencing, and whole-exome sequencing. Our scientists recapitulate the settings commonly used in human gut microbiome studies and design the experimental details. We guarantee the most complete description of gut bacterial species. We provide unprecedented resolution for taxonomic and functional characterization of the gut microbiota.

Gut Microbiota Genomic Analysis Services2

16S Ribosomal RNA Sequencing

16S sequencing is generally believed to be a robust, well-characterized technology that yields sufficient information about microbial communities' composition, starting from a relatively small number of sequences per sample. Creative Biolabs is dedicated to serving every unique need of our clients in analyzing the gut microbial community using 16S ribosomal RNA sequencing, by providing custom services to meet our clients’ R&D timeline and budget.

Gut Microbiota Genomic Analysis Services3

Shotgun Metagenomic Sequencing

The advent of culture-independent metagenomic technology has made it possible to study the population structure and genomic variation of microbes in their natural environment. By collecting sequence information about broad genomic regions, shotgun metagenomics allows a more accurate definition at the species level, thus yielding a detailed description of bacterial community.

Gut Microbiota Genomic Analysis Services4

Single-cell Genome Sequencing

Since about 60% of gut bacteria are unculturable, it is impossible to study individual bacterial genomes. However, thanks to the coming of single-cell genomics technology, which includes a microfluidic-based technique for sorting and whole-genome DNA amplification. This technology is valuable to extract genomic information from unculturable bacteria. Creative Biolabs is fully competent to serve as your one-stop-shop for microbiota genomic analysis.

Gut Microbiota Genomic Analysis Services5

Whole-Exome Sequencing

Whole-exome sequencing targets approximately 3% of the whole genome and provides coverage of more than 95% of the exons. Since it covers actionable areas of the genome to determine the variations in the exon regions, whole-exome sequencing is attractive for clinical application. This technology has been used to expand current knowledge of host-gut microbiota interactions and identify mechanisms involved in gut homeostasis and disease development.

With years of experience in gut microbiota genomic analysis, Creative Biolabs has gained significant knowledge in the characterization of gut microbiota. We are pleased to share our experience and help our customers in the research of gut microbiota. For more detailed information, please feel free to contact us or directly send us an inquiry.

Reference

  1. Ravcheev, D.A.; Thiele, I. Comparative genomic analysis of the human gut microbiome reveals a broad distribution of metabolic pathways for the degradation of host-synthetized mucin glycans and utilization of mucin-derived monosaccharides. Frontiers in genetics. 2017, 8:111.

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