Patients Genome Sequencing
Next-generation sequencing (NGS) is a technique that can fundamentally change the perceptions of scientific and diagnostic issues. This technology produces large amounts of sequencing data at lower price point leading to a series of breakthroughs, and unfolding a new era of bioinformatics and biostatistical data analysis.
Creative Biolabs is a leading provider of genomic services. The researchers in our team not only have profound knowledge not only in the field of NGS, but also in clinical research, molecular biology and related specialties. Their background and hands-on experiences enable to provide comprehensive services for our clients covering DNA and RNA sample preparation, extraction, genotyping and other NGS and gene expression studies.
Sequencing Platforms
Illumina sequencing technologies suitable for cost-effective de novo sequencing, can provide the coverage you need. IST is famous for its ability to produce raw reads in high accuracy, structure paired-end sequencing to create reliable backbone sequence. Here at CBL, we use multiple alignments of all reads to cross-reference and correct possible errors to ensure high-accuracy readings.
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HiSeq X system (151bp Paired-end)
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HiSeq2000 / MiSeq System (Paired-end, Mate pair)
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GS-FLX Titanium/Plus (Shotgun, Mate pair)
Sample Extraction and Assessment
The quality of the sequenced raw DNA directly relates to the conditions of the data when analyzing. In Creative Biolabs, we try our best to provide the best service we can. The pursuit and commitments on excellence enables us to provide a complete range of sample extraction services for our clients. You can expect a full service on automated DNA and RNA extractions pipelines for samples provided.
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After extraction: DNA reads will be analyzed to ensure sufficient fragment size and number for optimal library preparation.
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Post-library builds: Analyze fragment size and quantity again.
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NGS Run: Continuously monitor the quality score of the data, the final readings, the percentage of reads through the filter, and the average read length.
Genotyping Service
Through our newly developed genotyping platform, CBL provides genomic analysis for patients with cancers to help health professionals to examine multiple SNPs from thousands of samples in parallel, which, potentially, identifies genetic variants that may cause cancerous defects or changes on genetic traits.
Bioinformatics Analysis
Using gene expression profiles obtained from microarrays to qPCR and complex analysis of data from NGS, our team can conceptualize the WGS dataset. Even for bulk regions with repeated reads, we can still provide the most complete and accurate genomic sequence using our state-of-art technologies.
Creative Biolabs also offer other bioinformatic services including gene annotation services (such as genetic testing, functional assignment) and modification analysis (such as analysis of polymerase kinetics to detect possible modified bases), both of which can provide a deeper understanding on phenotype inconsistencies between organisms.
Over the past decade, we have successfully established business relationships with clients all around the world in regards to service pipeline of genome sequencing. Through continuous training and collaborations with scientist in the fields, we have formed quality infrastructures over years, allowing us provide diverse services from qPCR, arrays formations to later bioinformatic analysis.
Our high-performance infrastructure, continuous training, and ongoing collaboration with scientists in a variety of life science disciplines enable us to collaborate and be solution-oriented with our customers around the world.
Please feel free to contact us for detailed information.
For Research Use Only | Not For Clinical Use
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