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African Green Monkey Serum (NHP-BP003)
Category:Non-Human Primate (NHP) Serum Products
Tag: African Green Monkey, Serum
Tag: African Green Monkey, Serum
- African Green monkey has been seen as one of the most suitable NHP models for scientific research because of it being highly close to the Rhesus monkey. The offered product is obtained from African Green monkeys. The sample is confirmed as high-quality and negative for Herpes B Virus, retroviruses, SIV, SRV, and STLV. It can be applied to a lot of biochemical procedures such as PCR, WB, immunoprecipitation, immunofluorescent flow cytometry, and Biomarker Discovery.
Detailed Product Description
- Source: Healthy African green monkey
- Purity: No hemolysis or clotting.
- Applications: Suitable for various research fields including biomarker research, pharmacology, and toxicology.
- Storage Conditions: Store at -20 °C or -80 °C. Avoid freeze-thaw cycle.
Technical Specifications
- Collection Method: Serum is collected from rigorously screened healthy donors, and the collection process strictly adheres to animal welfare requirements. Obtained through centrifugation processing of non-anticoagulated whole blood, serum does not contain fibrinogen or other clotting factors and serves as a primary source for biomarkers.
- Quality Control: Strict accordance with biomedical standards.
- Available Formats: Frozen
Downloadable Resources
Published Data
FAQs
Customer Reviews
The article provides an in-depth analysis of a study that explored the immunization of African green monkeys with HPV-11 virus-like particles (VLPs) to assess the immune response, with an emphasis on neutralizing antibodies in both serum and genital mucosal secretions. Key observations are summarized below:
Immunization Efficacy: The study found that systemic immunization with HPV-11 VLPs resulted in the production of high-titer HPV-11 specific serum antibodies in African green monkeys. These antibodies were effective in neutralizing HPV-11 in an athymic mouse xenograft system, indicating potential protective benefits against HPV infection.
Mucosal Immunity: The research detected significant levels of HPV-11 neutralizing antibodies in the cervicovaginal secretions of the vaccinated monkeys. This finding suggests that systemic immunization can provoke a mucosal immune response, crucial for protecting the uterine cervix from HPV infection.
Experimental Data: Animals immunized with various doses (ranging from 10 to 700 µg) of HPV-11 VLPs exhibited similar geometric mean titers of HPV-11 specific IgG antibodies, indicating an effective dose-response relationship. Peak antibody titers were recorded two weeks post each immunization.
Neutralizing Antibody Correlation: There was a direct correlation between HPV-11 VLP-specific IgG titers and the extent of virus neutralization. Serum samples with IgG titers exceeding 500 were completely neutralizing.
Cross-Species Findings: The study also highlighted that HPV-16 VLPs triggered similar immune responses. Additionally, immunization of rhesus monkeys with HPV-11 VLPs yielded comparable results, which corroborates the reliability of the African green monkey model.
These findings underscore the utility of African green monkey serum as a crucial asset for the development and testing of vaccines against HPV and other viral infections. This research significantly contributes to the field of immunology and vaccine development.
Reference
- Robert S. Lowe., et al. "Human Papillomavirus Type 11 (HPV-11) Neutralizing Antibodies in the Serum and Genital Mucosal Secretions of African Green Monkeys Immunized with HPV-11 Virus-like Particles Expressed in Yeast." The Journal of Infectious Diseases,(1997) 1141–1145
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Q 1: How is African Green Monkey Serum prepared and what quality control measures are in place?
A: African Green Monkey Serum is prepared through a carefully controlled process to ensure its purity and effectiveness. The preparation involves: Blood Collection: Blood is collected from healthy African green monkeys under sterile conditions to prevent contamination. Clot Formation and Centrifugation: The blood is allowed to clot, and then it is centrifuged to separate the serum from the blood cells. Filtration: The serum is filtered to remove any remaining cellular debris and potential contaminants. Quality Control: Each batch of serum undergoes rigorous testing for the presence of pathogens, including Herpes B Virus, retroviruses, and other microbes. Sterility tests and endotoxin levels are also checked to ensure the serum is free from contaminants that could affect experimental results.
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Q 2: How does African Green Monkey Serum compare to other types of serum in terms of experimental outcomes?
A: African Green Monkey Serum offers several advantages over other types of serum: Physiological Relevance: Due to the close genetic and physiological similarities between African green monkeys and humans, the serum provides a more relevant model for human biology compared to sera from other animals like bovines or rodents. Enhanced Viral Growth: Vero cells, which thrive in African Green Monkey Serum, are more susceptible to viral infections than many other cell lines. This makes them ideal for producing high virus titers required for vaccine development and antiviral testing. Consistency: African Green Monkey Serum is produced under stringent quality control measures, ensuring batch-to-batch consistency. This consistency is critical for reproducible results in scientific research.
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Q 3: What are the specific applications of African Green Monkey Serum in virology research?
A: African Green Monkey Serum is particularly valuable in virology research for several reasons: Virus Propagation: The serum provides essential nutrients that support the growth of viruses in cell culture systems, making it crucial for studying viral life cycles and developing vaccines. Vero cells derived from African green monkey kidneys are widely used for this purpose. Antibody Production: The serum can be used to generate antibodies against specific viruses, which are essential tools for diagnostic tests and therapeutic applications. These antibodies can be used in various assays to detect viral infections. Pathogenesis Studies: Researchers use the serum in animal models to study the pathogenesis of viral diseases, including Nipah virus and SARS-CoV-2. These studies help understand how viruses interact with the host's immune system and identify potential therapeutic targets.
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Consistently Exceeded Expectations
As a researcher focusing on virology, the quality of my biological samples is crucial for the accuracy of my studies. The African Green Monkey Serum from Creative BioLabs has consistently exceeded my expectations. The serum's purity and reliability are unparalleled, helping me achieve reproducible results in my experiments. Additionally, the prompt delivery and excellent customer service provided by Creative BioLabs make them my go-to supplier for serum and other biological materials. I highly recommend this product to anyone in the field of biomedical research. -
Highly Satisfied
I have been using the African Green Monkey Serum for several months in my immunological assays, and I am highly satisfied with its performance. The serum is well-characterized and has proven to be very consistent across different batches, which is essential for my longitudinal studies. One minor drawback is the higher cost compared to some other suppliers, but the quality justifies the price. Overall, an excellent product that I would recommend to fellow researchers who can benefit from high-quality reagents. -
Highly Quality & Consistent Purity
As a researcher working on vaccine development, I have found the African Green Monkey Serum from Creative Biolabs to be indispensable. The high quality and consistent purity of the serum have significantly improved our viral culture processes, especially when working with Vero cells. The serum's compatibility with various cell lines ensures reliable and reproducible results, making it a vital component of our lab's resources. -
Exceptional Result
We have been using African Green Monkey Serum for our studies on viral pathogenesis, and the results have been exceptional. The serum supports robust cell growth and provides a physiologically relevant environment for our experiments. Creative Biolabs' commitment to ethical sourcing and stringent quality control measures ensures we receive a product that meets our high standards for research.
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NHP Biologicals from Creative Biolabs are for research, diagnostic, or manufacturing purposes only. They may not be intended for or are not approved for any other use.
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