Cynomolgus Monkey PBMCs- Rhesus Monkey PBMCs
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Cynomolgus Monkey Serum (NHP-BP001)
Category:Non-Human Primate (NHP) Serum Products
Tag: Cynomolgus Monkey, Serum
Tag: Cynomolgus Monkey, Serum
- Cynomolgus monkey is frequently used in scientific research, especially those involved in neuroscience and disease. This available serum product is collected from cynomolgus monkeys. The sample is high-quality and has been confirmed as negative for Herpes B Virus, retroviruses, SIV, SRV, and STLV. and can be used to perform a number of common biochemical experiments for desired research purposes.
Detailed Product Description
- Source: Healthy cynomolgus monkey
- Purity: No hemolysis or clotting.
- Applications: Suitable for various research fields including biomarker research, pharmacology, and toxicology.
- Storage Conditions: Store at -20 °C or -80 °C. Avoid freeze-thaw cycle.
Technical Specifications
- Collection Method: Serum is collected from rigorously screened healthy donors, and the collection process strictly adheres to animal welfare requirements. Obtained through centrifugation processing of non-anticoagulated whole blood, serum does not contain fibrinogen or other clotting factors and serves as a primary source for biomarkers.
- Quality Control: Strict accordance with biomedical standards.
- Available Formats: Frozen
Downloadable Resources
Published Data
FAQs
Customer Reviews
This paper summarizes research on the detection of cynomolgus monkey serum sample drug-specific circulating immune complexes (ICs). It highlights the generation of anti-drug antibodies (ADAs), known to form ICs with administered drugs, predisposing them to an alteration of NHP pharmacokinetics and therefore leading to adverse events. Both the respective developed assays in order to detect respective ICs indicated positive serum samples screened from respective tested animals. This study showed a good correlation of IC formation in the presence of ADAs and highlighted well-characterized kinetics of IC in full pharmacokinetics and immunogenicity evaluations. This study has supported cynomolgus monkey serum and the use of purified immunoglobulins in the development and establishing significance for developing and evaluating the immunogenicity immunoassays applicable for the biotherapeutics.
1Fig. 1. Summary of ligand binding assay formats.
Reference
- Piotr Pierog., et al. " Detection of drug specific circulating immune complexes from in vivo cynomolgus monkey serum samples." Journal of Immunological Methods 416 (2015) 124–136
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Q 1: How is Cynomolgus Monkey Serum tested for pathogens, and what certifications are important?
A: Testing a quality Cynomolgus Monkey Serum for a wide gamut of pathogens, such as herpes B virus, SIV, SRV, STLV, etc., is mandatory. At the very least, some of the well-reputed certification bodies, including USDA or its equivalents, could provide a little solace to the researchers in such aspects that would ensure the minimum ethical treatment of animals and at least a certain level of standards safety and quality of the produced serum.
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NHP Biologicals from Creative Biolabs are for research, diagnostic, or manufacturing purposes only. They may not be intended for or are not approved for any other use.
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