Caspase 7 Monoclonal Antibody (R4LA) (NHP-AB178)

• This product is an antibody that was generated by immunizing mouse against recombinant human CASP7. It is used only in in vitro assays.

Detailed Product Description

• Introduction: Caspase 7 is part of a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. The apoptotic subfamily can be further divided into initiator caspases, which are activated in response to death signals, and executioner caspases, which are activated by the initiator caspases and are responsible for cleavage of cellular substrates that ultimately lead to cell death. Caspase 7 is an executioner caspase that was identified based on its homology with caspases 1 and 3, as well as the C. elegans cell death protein CED-3. Alternative splicing of Caspase-7 mRNA results in the production of 3 distinct isoforms. Caspase-7 activity can be directly inhibited by XIAP expression. Alternative splicing results in four transcript variants, encoding three distinct isoforms of Caspase 7.
• Conjugate: None
• Antibody Isotype: IgG
• Applications: IHC; WB

Technical Specifications

• Host Species: Mouse
• Species Reactivity: Dog; Hamster; Human; Monkey; Mouse; Pig; Rabbit; Rat; Sheep
• Immunogen: Recombinant human CASP7

Product Property

• Purification: Protein G Column
• Format: Liquid
• Concentration: 1 mg/mL
• Buffer: PBS (10 mM sodium phosphate, pH 7.2, 50 mM sodium chloride, 0.1 mM PMSF)
• Storage: Short term: 4˚C. Long term: Store at -20˚C. Avoid freeze-thaw cycles.

Target Information

• Target: Caspase 7
• Clone: R4LA
• Clonality: Monoclonal
• Related Disease: Diseases associated with CASP7 include Type 1 Diabetes Mellitus 17 and Aleutian Mink Disease.
• Alternative Names: Apoptotic protease Mch-3; CASP-7; caspase 7, apoptosis-related cysteine peptidase; caspase 7, apoptosis-related cysteine protease; Caspase-7; Caspase-7 subunit p11; Caspase-7 subunit p20; CMH-1; ICE-LAP3; ICE-like apoptotic protease 3; OTTHUMP00000020511; OTTHUMP00000020513; OTTHUMP00000020514; RP11-211N11.6
• Entrez Gene ID: 840