Semaphorin-4D Monoclonal Antibody (SL24J) (NHP-AB247)

• This product is an antibody that was generated by immunizing mouse against PHA stimulated human peripheral blood lymphocytes. It is used only in in vitro assays.

Detailed Product Description

• Introduction: Semaphorins are neuronal chemorepellants that direct pioneering neurons during nervous system development. CD100 (also known as semaphorin 4d), a 150 kDa homodimer, is a novel semaphorin that induces B cells to aggregate and improves their viability in vitro. CD100 modifies CD40-CD40L B cell signaling by augmenting B cell aggregation and survival and down regulating CD23 expression. CD72 is a lymphocyte receptor for the class IV semaphorin CD100, which is involved in regulating B cell signaling. CD100 is expressed on resting and PHA stimulated T cells. The protein is weakly expressed on NK cells, EBV transformed B cells, monocytes and tumor/peripheral blood T cell lines, and at higher density on activated T cells and B cells.
• Conjugate: None
• Antibody Isotype: IgG1κ
• Applications: Flow Cytometry; Func; IF; WB

Technical Specifications

• Host Species: Mouse
• Species Reactivity: Human; Monkey; Mouse
• Immunogen: PHA stimulated human peripheral blood lymphocytes

Product Property

• Purification: Protein G affinity chromatography
• Format: Liquid
• Concentration: 0.2 mg/mL
• Buffer: PBS with 0.1 mg/ml BSA and 0.05% sodium azide
• Storage: Store at 4⁰C. Avoid freez-thaw cycles.

Target Information

• Clone: SL24J
• Clonality: Monoclonal
• Alternative Names: A8; BB18; CD100; GR3; M-Sema G; sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D; sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, 4D; Sema J; semaphorin H; Semaphorin-4D; Semaphorin-C-like 2; Semaphorin-J
• Entrez Gene ID: 10507