NGS-Based Immuno-Oncology Research
As a well-recognized expert in the field of next generation sequencing (NGS) based cancer research, Creative Biolabs offers our worldwide clients high-quality and comprehensive NGS solutions to advance the progression of cancer research. We have equipped a world-leading high-throughput sequencing platform including Illumina HiSeq X Ten, Illumina HiSeq, Illumina MiSeq, and Ion PGM™, which meets requirements for various sequencing projects. Our strict sequencing process and quality control enable to deliver reliable and accurate data. Besides, we have also organized an excellent scientist team who can customize an optimal bioinformatic analysis solution according to the requirements of your project. With a professional expert team and capabilities ranging from preparation of nucleic acid samples, library construction and sequencing to data QC and analysis, we are dedicated to supporting a series of high-throughput sequencing and analysis services to advance the progress of cancer research.
Tumor Mutational Burden (TMB) Analysis
TMB is a genomic biomarker that prediction of response to immune checkpoint inhibitors (ICIs) such as PD-(L)1 inhibitors. The number of somatic mutations within the coding region of a tumor genome is regarded as TMB, which is associated with response to ICIs. Leveraging our whole exome sequencing (WES) sequencing technologies and a proprietary algorithmic approach for TMB analysis, we support TMB analysis services for assessing the response to checkpoint inhibitor immunotherapy.
Variants Analysis
Cancer is a type of genetic disease due to variants including germline variants and somatic variants that could play important roles in tumor development. Creative Biolabs supports a full range of variant analysis services including genotyping, variant calling, annotation, and prioritization for global customers based on our powerful sequencing technologies.
Structural Variants Detection
Gene structural variants including deletions, insertions, inversions, mobile-element transpositions, translocations, tandem repeats, and copy number variants contribute to cancer development and progression. We also support high-quality and low-cost structural variant detection services based on our whole exome sequencing (WES) and whole genomic sequencing (WgS) technologies. We ensure to deliver the most reliable results with the lowest false positive.
Copy-Number Variation Analysis
Copy-number variation, also known as CNV, is a type of structural variant, implicated in cancer susceptibility, metastasis, and treatment. Equipped with advanced and powerful technology platforms and professional bioinformatic analysis experts, Creative Biolabs provides the best WES services for the detection of de novo and rare CNVs for our customers.
Tumor-Specific Neoantigen Identification
Tumor neoantigens are a class of crucial biomarkers for tumor detection and are also regarded as promising targets for tumor treatment. Creative Biolabs has accumulated extensive experiences in tumor neoantigen identification and is committed to offering tumor neoantigen identification services based on our cutting-edge WES technology.
Personal Tumor-Specific Neoantigen Vaccine Development
Creative Biolabs is confident in offering high-quality and low-cost personal tumor-specific neoantigen vaccine development services. Employing advanced WES sequencing technology, we can identify potential vaccine candidates.
Minimal Residual Disease (MRD) Monitoring
MRD refers to cancer cells that may remain in the body of a person with lymphoid cancer after treatment. Monitoring of MRD is useful to predict the prognosis of adult patients with leukemia, particularly acute promyelocytic leukemia and childhood acute lymphoblastic leukemia. By WES technology, we support MRD monitoring services.
Biomarkers Discovery
Creative Biolabs is skilled in discovering novel biomarkers based on state-of-the-art sequencing technologies to advance and facilitate the development of cancer diagnosis tools and therapeutic drugs.
Microsatellite Instability Analysis
Microsatellite instability (MSI) is a form of genomic instability caused by the insertion or deletion of duplicate bases during DNA replication and the failure of the mismatch repair system to correct these errors. Employing world-leading technology platforms and proprietary bioinformatics tools, we offer the most comprehensive MSI to facilitate your cancer research.
Immune Repertoire Germline Genes and Alleles Identification
Creative Biolabs has accumulated extensive experience by participating in several BCR/TCR repertoire sequencing projects. We are able to provide high-quality immune repertoire (V(D)J) sequencing and analysis services for global customers in a high-efficient manner.
One-stop Service for Cancer 3D Model
As an excellent expert in the field of cancer research, we are committed to providing end-to-end cancer 3D model services including development of cancer 3D models, NGS for cancer 3D models, and therapeutic validation in the cancer 3D model.
Circle-Seq-based eccDNA Identification
eccDNAs, also known as extrachromosomal circular DNA elements are widely present in eukaryotic cells including humans. eccDNA plays a crucial role in the development of cancer, thus enable it very important for identification of eccDNA. We provide one-stop eccDNA sequencing and analysis services from sample preparation to reliable data delivery, helping global customers to identify novel eccDNAs in tumor cells.
Tumor Microenvironment Analysis by RNA-Seq
The tumor microenvironment is the cellular environment that is composed of tumor cells, immune cells, fibroblasts, bone marrow-derived inflammatory cells, lymphocytes, signaling molecules, and the extracellular matrix. The physiological state of the tumor microenvironment is closely related tumor development. Creative Biolabs employs RNA sequencing technologies and state-of-the-art analytical tools to support the most comprehensive tumor microenvironment analysis services at the most competitive price.
We are committed to becoming your reliable partner in the field of NGS-based cancer research. We are confident in offering the best and comprehensive NGS sequencing and analysis services for cancer research in a time-saving and cost-effective manner. If you are interested in our services, please feel free to contact us for more details.
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Note: Our sequencing services are for Research Use Only. Not For Clinical Diagnosis.
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