Whole Exome Sequencing (WES) Service for Cancer

Background Services Advantages Applications Workflow Deliverables Q&As Resource

Whole exome sequencing (WES) is especially suitable for patients who are looking for a unifying diagnosis for multiple medical problems. With years of research and development experience in the field of next-generation sequencing (NGS), Creative Biolabs has established a cutting-edge SuPrecision™ platform for NGS services. WES with our comprehensive bioinformatics pipeline is a powerful tool to study a person’s exome, especially cancer patient. We are pleased to use our extensive experience and advanced platform to offer the best WES service to satisfy each demand from our customers.

The Background of WES

With the advent of NGS, it is now feasible to sequence large amounts of DNA. The exome (the protein-coding region of the genome) represents less than 2% of the genome. WES provides coverage of more than 95% of the exons, which harbor the majority of the geneWhole Exome Sequencing (WES) Service (Creative Biolabs Authorized)tic variants associated with human disease phenotypes, making WES a cost-effective alternative to whole-genome sequencing. WES offers researchers the ability to use sequencing and analysis resources more efficiently by focusing on the most relevant portion of the genome and facilitates the discovery and validation of common and rare variants. WES provides many of the benefits of whole-genome sequencing (WGS) with greatly reduced resources. WES can efficiently identify coding variants across a wide range of applications, including population genetics, genetic disease, and cancer studies.

Cancer WES Service at Creative Biolabs

Equipped with world-leading technology platforms and professional scientific staff, Creative Biolabs has accumulated rich experience in performing every step for WES and comprehensive WES sequencing bioinformatics analysis. Our workflow of WES consists of 1) experimental design, 2) library preparation & exome enrichment, 3) sequencing and 4) variant calling & downstream analysis. Creative Biolabs accepts purified genomic DNA, frozen cell pellets and formalin-fixed paraffin-embedded (FFPE) thin tissue sections (slides) as starting material for WES projects.

Whole Exome Sequencing (WES) Service (Creative Biolabs Authorized)

Key Advantages Include But Are Not Limited to:

  • Identifying variants across a wide range of applications
  • Availability of major exome targeting technologies
  • Comprehensive coverage of coding regions
  • The customizable depth of coverage to focus on common/rare variants
  • A comprehensive suite of bioinformatics solutions
  • Dedicated support from highly professional scientists
  • Fast turnaround time

Applications of Our Cancer WES Service Include But Are Not Limited to:

WES Workflow at Creative Biolabs

  • Whole exome sequencing workflow. (Creative Biolabs Original)
    Experimental design

  • Whole exome sequencing workflow. (Creative Biolabs Original)
    Library preparation & exome enrichment
  • Whole exome sequencing workflow. (Creative Biolabs Original)
    Sequencing

  • Whole exome sequencing workflow. (Creative Biolabs Original)
    Variant calling & downstream analysis

Deliverables

All customers receive their raw data as FASTQ files. Variant discovery and customizable data analysis packages are available by request.

Enriched experience associated with state-of-the-art facilities, Creative Biolabs can offer high-quality cancer WES service to all our global customers. Our scientists are confident in providing our customers with the most reliable and clinically actionable results to facilitate their meaningful genomic research.

Please contact us for more information and a detailed quote.

Q&As

Q: What types of cancer can be studied using WES?
A: WES can be applied to various types of cancer, including breast, lung, colorectal, and prostate cancers. It is particularly useful in identifying mutations in tumors that can inform treatment strategies and predict patient response to therapies.
Q: What are the data requirements for WES in cancer research?
A: For WES in cancer research, high-quality DNA samples are essential. Typically, genomic DNA from blood, saliva, or tumor tissue is required, with specific quantity and purity standards to ensure accurate sequencing results. The sequencing depth may vary depending on the study's goals.
Q: How is the data from WES analyzed?
A: Yes, WES can be used to monitor cancer progression and treatment response by analyzing tumor DNA at different time points. This helps track the emergence of new mutations, resistance mechanisms, and changes in tumor genetics over time, aiding in the adjustment of treatment strategies.
Q: Can WES be used for monitoring cancer progression and treatment response?
A: Yes, WES can be used to monitor cancer progression and treatment response by analyzing tumor DNA at different time points. This helps track the emergence of new mutations, resistance mechanisms, and changes in tumor genetics over time, aiding in the adjustment of treatment strategies.
Q: How does WES help in personalized cancer treatment?
A: WES helps personalize cancer treatment by identifying specific genetic mutations in a patient's tumor. This information can guide the selection of targeted therapies that are more likely to be effective based on the genetic profile of the cancer, improving treatment outcomes.

Resources

Infographics

Podcast

Note: Our sequencing services are for Research Use Only. Not For Clinical Diagnosis.
Related Services:
  1. Whole Genome Sequencing (WGS) Service for Cancer
  2. Targeted Sequencing Service for Cancer
  3. Whole Transcriptome Sequencing (WTS) Service for Cancer
  4. Immune Repertoire Sequencing (Rep-Seq) Service for Cancer
  5. Epigenomics Service
  6. Three-dimensional (3D) Genomics Service
  7. Metagenomics Sequencing Service for Cancer
  8. ctDNA Sequencing
  9. Single Cell Squencing for Cancer
  10. Spatial Transcriptome Sequencing for Cancer
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