Whole Genome Sequencing (WGS) Service for Cancer

Introduction Services Features Applications Workflow Q&As Resource

Whole genome sequencing (WGS) is a key driver for many medical research projects in cancer and complex genetic disorders. Creative Biolabs has established the high-throughput SuPrecision™ platform for large-scale sequencing services. Based on this advanced platform, we can provide the most comprehensive cancer WGS sequencing bioinformatics analysis for our global customers.

The Background of Cancer WGS

A representative Circos plot of cancer genome structure from WGS analysis, which indicates structural variants and copy number alterations in all human chromosomes (Creative Biolabs Authorized)Fig.1 A representative Circos plot of cancer genome structure from WGS analysis, which indicates structural variants and copy number alterations in all human chromosomes (Nakagawa & Fujita 2018).

Researchers have found that DNA variations outside the exons can affect gene activity and protein production and lead to genetic disorders--variations that whole exome sequencing would miss. WGS, also known as complete genome sequencing, determines the order of all the nucleotides in an individual's DNA and can determine variations in any part of the genome at a single time. WGS represents the ultimate step in assaying human genetic variation at the base sequence level. The development of WGS, combined with the falling cost of the technology holds great promise for accelerating the delivery of genetic predictors of human diseases and related treatment. Genome sequencing is backed by automated DNA sequencing methods and computer software to assemble the enormous sequence data. It can be divided into four stages: (1) preparation of clones comprising the entire genome of an organism; (2) collection of DNA sequences of clones; (3) generation of contig assembly; and (4) database development. Genome sequencing is the most direct method of detecting mutations, such as single nucleotide polymorphisms and copy number variations. Whole genome sequencing has largely been used as a research tool and has been introduced to clinics. For personalized medicine, whole genome sequence data will be an important tool to guide therapeutic intervention.

Cancer WGS Service in Creative Biolabs

Creative Biolabs uses the advanced SuPrecision™ platform to support researchers all over the world with their genome sequencing needs. Our capabilities include but are not limited to: 1) germline variant detection, 2) somatic variant detection, 3) whole genome re-sequencing, 4) de novo genome assembly, 5) copy number variation, 6) structural variant discovery.

Key Features and Advantages of Cancer WGS Service in Creative Biolabs Including but Not Limited to:

  • No PCR amplification bias
  • Up to 99.99% accuracy
  • Identify potential causative variants
  • Detect DNA modifications without bisulfite treatment
  • Identify large structural variants
  • Phase alleles and variants
  • Highly professional Ph.D. level scientists
  • Advanced SuPrecision™ platform

Applications of WGS Including but Not Limited to:

  • Capture both large and small variants that might otherwise be missed
  • Unknown genes can be identified as contributing to a disease state
  • Obtain high quality de novo assemblies of large and complex genomes
  • The change of genetic predisposition caused by lifestyle or environmental factor can be identified
  • Genome information can provide valuable information to create personalized plans to treat cancers

WGS Workflow in Creative Biolabs

Whole genome sequencing workflow. (Creative Biolabs Original)

Equipped with world-leading technology platforms and professional scientific staff, Creative Biolabs has accumulated rich experience in providing WGS service. We are pleased to use our extensive experience and advanced platform to offer the best WGS service to satisfy each demand from our customers.

Please contact us for more information and a detailed quote.

Q&As

Q: Can WGS be used for all types of cancer?
A: WGS is applicable to a wide range of cancers, including solid tumors and hematological malignancies. It is particularly useful for cancers with complex genetic alterations and those that are difficult to diagnose using conventional methods.
Q: What types of samples are required for WGS?
A: WGS typically requires both tumor tissue and a matched normal sample, such as blood or saliva. This allows for the comparison of cancerous and normal DNA to identify somatic mutations specific to the tumor.
Q: How is the data from WGS analyzed?
A: Data from WGS is processed using advanced bioinformatics tools to identify genetic variants and mutations. This includes quality control, alignment to reference genomes, and variant calling. The results are interpreted to provide insights into the genetic underpinnings of the cancer.
Q: Can WGS be integrated into routine clinical practice for cancer?
A: While WGS holds great promise, integrating it into routine clinical practice requires addressing challenges such as cost, data interpretation, and the need for specialized infrastructure and expertise. However, as sequencing costs decrease and bioinformatics tools improve, WGS is becoming more feasible for clinical use.
Q: What are the limitations of WGS in cancer research?
A: Despite its comprehensive nature, WGS can be costly and time-consuming. It may also generate large amounts of data, requiring sophisticated computational tools and expertise for analysis. Additionally, some small-scale genetic changes may be missed if not enough DNA is sequenced.

Resources

Infographics

Podcast

Note: Our sequencing services are for Research Use Only. Not For Clinical Diagnosis.
Related Services:
  1. Whole Exome Sequencing (WES) Service for Cancer
  2. Targeted Sequencing Service for Cancer
  3. Whole Transcriptome Sequencing (WTS) Service for Cancer
  4. Immune Repertoire Sequencing (Rep-Seq) Service for Cancer
  5. Epigenomics Service
  6. Three-dimensional (3D) Genomics Service
  7. Metagenomics Sequencing Service for Cancer
  8. ctDNA Sequencing
  9. Single Cell Squencing for Cancer
  10. Spatial Transcriptome Sequencing for Cancer
Online Inquiry
ISO 9001 Certified - Creative Biolabs Quality Management System.
logo
Inquiry Basket