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Anti-CD70-VC-rachelmycin ADC

Anti-CD70-VC-rachelmycin ADC (CAT#: ADC-W-367)

Name: Anti-CD70-VC-rachelmycin ADC
SKU: ADC-W-367
Rating: 5 (1 reviews)

This ADC product is comprised of an anti-CD70 monoclonal antibody conjugated via a VC linker to a rachelmycin. The rachelmycin is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, rachelmycin binds to DNA, causes DNA damage.

Product Information
ADC Target
ADC Antibody
ADC Linker
ADC payload drug

Antibody clone #
h1F6

Name
CD70

Alternative Names
CD70; CD70 molecule; CD27L; CD27LG; TNFSF7; CD70 antigen; CD27-L; CD27 ligand; Ki-24 antigen; surface antigen CD70; tumor necrosis factor ligand superfamily member 7; tumor necrosis factor (ligand) superfamily, member 7;

Target Entrez Gene ID
970

Target UniProt ID
P32970

Overview
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis.

Overview
Humanized Anti-CD70 lgG1 Antibody, clone # h1f6

Clone #
h1F6

Species Reactivity
Human

Name
VC (valine-citrulline)

Description
Peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.

Name
CC-1065 (rachelmycin)

Description
CC-1065 is a kind of natural DNA alkylators and can be used as anti-tumor therapic agent because it can bind tightly to the minor groove of DNA and then react covalently with adenine bases.

For Research Use Only. NOT FOR CLINICAL USE.

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Scientific Resources

CAMouse™-Fully Human Antibody Generation Platform

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ADC-W-376	Anti-CD70 (clone h1F6)-β-glucuronide-doxorubicin ADC	β-glucuronide linker	doxorubicin
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ADC-W-954	Anti-CD70 (Vorsetuzumab)-MC-Vc-PAB-SN38 ADC	MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl)	SN-38 (7-ethyl-10-hydroxycamptothecin)
ADC-W-587	Anti-CD70 (clone h1F6 )-Mc-VC-PABC-MMAE ADC	MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl)	MMAE (Monomethyl auristatin E)
ADC-W-567	Anti-CD70-DM1 ADC	Noncleavable thioether linker	DM1 (N2’-Deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine)

CAT#	Product Name	Linker	Payload
ADC-AA-052	Protein A-VC-MMAE ADC	VC (valine-citrulline)	MMAE (Monomethyl auristatin E)
ADC-W-462	Anti-GPNMB-VC-MMAE ADC	VC (valine-citrulline)	MMAE (Monomethyl auristatin E)
ADC-W-477	Anti-NECTIN4-VC-MMAE ADC	VC (valine-citrulline)	MMAE (Monomethyl auristatin E)
ADC-W-486	Anti-CD37-VC-MMAE ADC	VC (valine-citrulline)	MMAE (Monomethyl auristatin E)
ADC-W-565	Anti-EDNRB-VC-MMAE ADC	VC (valine-citrulline)	MMAE (Monomethyl auristatin E)

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