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- Anti-EphA4-calicheamicin ADC
Anti-EphA4-calicheamicin ADC (CAT#: ADC-W-556)
This ADC product is comprised of an Anti-EPHA4 antibody conjugated via a linker to Calicheamicin. The Calicheamicin is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, Calicheamicin binds to DNA, causes DNA damage.
- ADC Target
- ADC Antibody
- ADC payload drug
- Name
- EphA4
- Alternative Names
- EPHA4; EPH receptor A4; SEK; HEK8; TYRO1; ephrin type-A receptor 4; EK8; EPH-like kinase 8; TYRO1 protein tyrosine kinase; tyrosine-protein kinase TYRO1; tyrosine-protein kinase receptor SEK; receptor protein-tyrosine kinase HEK8;
- Target Entrez Gene ID
- 2043
- Target UniProt ID
- A0A024R452
- Overview
- This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands.
- Overview
- Anti-EphA4 Antibody
- Species Reactivity
- Human
- Name
- Calicheamicin
- Description
- Calicheamicin,produced by prokaryotic microorganisms, are a group of DNA cleaving agents with similar structure that binds in the minor grove of DNA in a relatively sequence-specific manner.
For Research Use Only. NOT FOR CLINICAL USE.
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Other Products
Same Payload
| CAT# | Product Name | Linker | Payload |
| ADC-W-464 | Anti-CD33 (clone hP67.6)-AcBut-Calicheamicin ADC | AcBut (4-(4-acetylphenoxy)butanoic acid) | Calicheamicin |
| ADC-W-338 | Anti-CD22 (Inotuzumab)-hydrazone-Calicheamicin ADC | hydrazone | calicheamicin |
| ADC-W-008 | Anti-TPBG (clone A1)-AcBut-calicheamicin ADC | AcBut [-(4' acetyl phenoxy) butanoic acid] | calicheamicin |
| ADC-W-332 | Anti-CD22 (clone 10F4)-AcBut-Calicheamicin ADC | AcBut [-(4' acetyl phenoxy) butanoic acid] | calicheamicin |
| ADC-W-357 | Anti-CD33 (clone HuM195)-AcBut-Calicheamicin ADC | AcBut [-(4' acetyl phenoxy) butanoic acid] | calicheamicin |
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