Home
Products
Customized ADCs
CD33
Anti-CD33 (clone hP67.6)-AcBut-Calicheamicin ADC

Anti-CD33 (clone hP67.6)-AcBut-Calicheamicin ADC (CAT#: ADC-W-464)

This ADC product is comprised of an Anti-CD33 antibody (clone hP67.6) conjugated via a AcBut linker to Calicheamicin. The Calicheamicin is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, Calicheamicin binds to DNA, causes DNA damage.

Product Information
ADC Target
ADC Antibody
ADC Linker
ADC payload drug

Antibody clone #
hP676

Similar to
gemtuzumab ozogamicin

Name
CD33

Alternative Names
CD33; CD33 molecule; p67; SIGLEC3; SIGLEC-3; myeloid cell surface antigen CD33; gp67; CD33 antigen (gp67); sialic acid binding Ig-like lectin 3; sialic acid-binding Ig-like lectin 3;

Target Entrez Gene ID
945

Target UniProt ID
P20138

Overview
CD33 or Siglec-3 is a transmembrane receptor expressed on cells of myeloid lineage. It is usually considered myeloid-specific, but it can also be found on some lymphoid cells. It binds sialic acids, therefore is a member of the SIGLEC family of lectins.

Overview
Anti-CD33 lgG4κ Antibody, clone # hP676

Generic name
gemtuzumab

Clone #
hP676

Species Reactivity
Human

Name
AcBut (4-(4-acetylphenoxy)butanoic acid)

Description
Acid-labile linkers, belonging to chemically cleavable linkers, are designed based on a pH-dependent release mechanism and remain intact during systemic circulation in the blood's neutral pH environment (pH 7.3–7.5) but to undergo hydrolysis and release drug once the ADC is internalized into mildly acidic endosomal (pH 5.0–6.5) and lysosomal (pH 4.5–5.0) compartments of the cell.

Name
Calicheamicin

Description
Calicheamicin,produced by prokaryotic microorganisms, are a group of DNA cleaving agents with similar structure that binds in the minor grove of DNA in a relatively sequence-specific manner.

For Research Use Only. NOT FOR CLINICAL USE.

Published Data

+ Submit Publications

Submit a review or a question

Scientific Resources

CAMouse™-Fully Human Antibody Generation Platform

Reviews

Literature

Protocol

Customer Reviews and FAQs

There are currently no Customer reviews or questions for ADC-W-464. Click the button above to contact us or submit your feedback about this product.

Quick Links

ADC Toxins

Drug-linker Complexes

Customized ADCs

Anti-Ab ADCs

Other Products

Same Target Same Linker Same Payload

CAT#	Product Name	Linker	Payload
ADC-W-2538	Anti-CD33 (Gemtuzumab)-SPDB-DM4 ADC	SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate)	DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
ADC-W-2541	Anti-CD33 (Gemtuzumab)-MC-Vc-PAB-SN38 ADC	MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl)	SN-38 (7-ethyl-10-hydroxycamptothecin)
ADC-W-492	Anti-CD33 (h2H12ec)-Mc-VC-SGD-1882 ADC	mc-VC (maleimidocaproyl-valine-alanine)	SGD-1882
ADC-W-2542	Anti-CD33 (Gemtuzumab)-MC-Vc-PAB-DMEA-(PEG2)-duocarmycin SA ADC	MC-Vc-PAB-DMEA-(PEG2)	duocarmycin SA
ADC-W-115	Anti-CD33 (clone h2H12)-Mc-MMAF ADC	Mc (maleimidocaproyl)	MMAF (Monomethyl auristatin F)

CAT#	Product Name	Linker	Payload
ADC-W-461	Anti-CD22 (clone G5/44)-AcBut-CalichDMH ADC	AcBut (4-(4-acetylphenoxy)butanoic acid)	CalichDMH

CAT#	Product Name	Linker	Payload
ADC-W-332	Anti-CD22 (clone 10F4)-AcBut-Calicheamicin ADC	AcBut [-(4' acetyl phenoxy) butanoic acid]	calicheamicin
ADC-W-556	Anti-EphA4-calicheamicin ADC		Calicheamicin
ADC-W-357	Anti-CD33 (clone HuM195)-AcBut-Calicheamicin ADC	AcBut [-(4' acetyl phenoxy) butanoic acid]	calicheamicin
WJY-0423-LS106	Protein A-Calicheamicin ADC	Cleavable linkers	Calicheamicin
ADC-W-008	Anti-TPBG (clone A1)-AcBut-calicheamicin ADC	AcBut [-(4' acetyl phenoxy) butanoic acid]	calicheamicin

Online Inquiry

Welcome! For price inquiries, please feel free to contact us through the form on the left side. We will get back to you as soon as possible.