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- Anti-CD33 (clone HuM195)-AcBut-Calicheamicin ADC
Anti-CD33 (clone HuM195)-AcBut-Calicheamicin ADC (CAT#: ADC-W-357)
This ADC product is comprised of an anti-CD33 monoclonal antibody (clone HuM195) conjugated via a AcBut linker to a Calicheamicin. The Calicheamicin is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, Calicheamicin binds to DNA, causes DNA damage.
- Product Information
- ADC Target
- ADC Antibody
- ADC Linker
- ADC payload drug
- Antibody clone #
- HuM195
- Name
- CD33
- Alternative Names
- CD33; CD33 molecule; p67; SIGLEC3; SIGLEC-3; myeloid cell surface antigen CD33; gp67; CD33 antigen (gp67); sialic acid binding Ig-like lectin 3; sialic acid-binding Ig-like lectin 3;
- Target Entrez Gene ID
- 945
- Target UniProt ID
- P20138
- Overview
- CD33 or Siglec-3 is a transmembrane receptor expressed on cells of myeloid lineage. It is usually considered myeloid-specific, but it can also be found on some lymphoid cells. It binds sialic acids, therefore is a member of the SIGLEC family of lectins.
- Overview
- Humanized Anti-CD33 lgG1 Antibody, clone # HuM195
- Clone #
- HuM195
- Species Reactivity
- Human
- Name
- AcBut [-(4' acetyl phenoxy) butanoic acid]
- Description
- Disulfide Linkers, are extensively exploited as a chemically labile linkage. Since the release of disulfide-linked drugs requires a cytoplasmic thiol cofactor, such as glutathione (GSH). Disulfides maintain stable at physiological pH and only when ADCs are internalized inside cells, the cytosol provides reducing environment including intracellular enzyme protein disulfide isomerase, or similar enzymes, drugs can be released.
- Name
- calicheamicin
- Description
- Calicheamicin,produced by prokaryotic microorganisms, are a group of DNA cleaving agents with similar structure that binds in the minor grove of DNA in a relatively sequence-specific manner.
For Research Use Only. NOT FOR CLINICAL USE.
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CAT# | Product Name | Linker | Payload |
ADC-W-814 | Anti-CD33 (Lintuzumab)-MC-MMAF ADC | MC (maleimidocaproyl) | MMAF |
ADC-W-2540 | Anti-CD33 (Gemtuzumab)-MC-Vc-PAB-MMAE ADC | MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) | MMAE |
ADC-W-2542 | Anti-CD33 (Gemtuzumab)-MC-Vc-PAB-DMEA-(PEG2)-duocarmycin SA ADC | MC-Vc-PAB-DMEA-(PEG2) | duocarmycin SA |
ADC-W-2537 | Anti-CD33 (Gemtuzumab)-SMCC-DM1 ADC | SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate) | DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine) |
ADC-W-816 | Anti-CD33 (Lintuzumab)-MC-Vc-PAB-SN38 ADC | MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) | SN-38 (7-ethyl-10-hydroxycamptothecin) |
CAT# | Product Name | Linker | Payload |
ADC-W-019 | Anti-EFNA4 (clone huE47)-AcBut-CM ADC | AcBut [-(4' acetyl phenoxy) butanoic acid] | CM (N-acetyl-y-calicheamicin dimethyl hydrazide) |
ADC-W-008 | Anti-TPBG (clone A1)-AcBut-calicheamicin ADC | AcBut [-(4' acetyl phenoxy) butanoic acid] | calicheamicin |
ADC-W-018 | Anti-EFNA4 (clone huE22)-AcBut-CM ADC | AcBut [-(4' acetyl phenoxy) butanoic acid] | CM (N-acetyl-y-calicheamicin dimethyl hydrazide) |
ADC-W-332 | Anti-CD22 (clone 10F4)-AcBut-Calicheamicin ADC | AcBut [-(4' acetyl phenoxy) butanoic acid] | calicheamicin |
ADC-W-459 | Anti-FUT3 (clone hu3S193)-AcBut-CalichDMH ADC | AcBut [-(4' acetyl phenoxy) butanoic acid] | CalichDMH |
CAT# | Product Name | Linker | Payload |
ADC-W-008 | Anti-TPBG (clone A1)-AcBut-calicheamicin ADC | AcBut [-(4' acetyl phenoxy) butanoic acid] | calicheamicin |
ADC-W-338 | Anti-CD22 (Inotuzumab)-hydrazone-Calicheamicin ADC | hydrazone | calicheamicin |
ADC-W-464 | Anti-CD33 (clone hP67.6)-AcBut-Calicheamicin ADC | AcBut (4-(4-acetylphenoxy)butanoic acid) | Calicheamicin |
WJY-0423-LS106 | Protein A-Calicheamicin ADC | Cleavable linkers | Calicheamicin |
ADC-W-556 | Anti-EphA4-calicheamicin ADC | Calicheamicin |
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